ELECTRODERMAL DYSFUNCTIONS AND SCHIZOPHRENIA

皮肤电功能障碍和精神分裂症

• 批准号: 6186294
• 负责人: MICHAEL Edward DAWSON
• 金额: $ 11.07万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6186294
• 关键词: behavior prediction; behavioral /social science research tag; clinical research; cognition disorders; galvanic skin response; human subject; neural information processing; neural inhibition; neuropsychological tests; neuropsychology; psychophysiology; relapse /recurrence; schizophrenia; startle reaction

DESCRIPTION (adapted from applicant's abstract): The present application proposes a program of studies organized around four broad issues dealing with the clinical, cognitive, functional, and neurophysiological significance of electrodermal activity and prepulse inhibition (PPI) of the startle eyeblink reflex. The four issues involve testing predictions derived from a vulnerability stress model of schizophrenia. The first (clinical) issue is whether anomalies in tonic electrodermal activity index a "transient intermediate state" that precedes symptomatic episodes in vulnerable individuals. The second (cognitive) issue is whether PPI can index both automatic and controlled cognitive processes when tested in the investigator's "attention-to-prepulse" paradigm. The third (functional) issue concerns whether PPI reflects a sensory inhibition process, while phasic electrodermal responses reflect sensory intake. A fourth (neurophysiological) issue addresses whether brain structural abnormalities are related to electrodermal and PPI anomalies in schizophrenia. These four issues will be tested in randomly selected college students, those selected to be putatively "at-risk" and in schizophrenic outpatients.

描述（改编自申请人摘要）：本申请