ELECTRODERMAL DYSFUNCTIONS AND SCHIZOPHRENIA

皮肤电功能障碍和精神分裂症

• 批准号: 3386235
• 负责人: MICHAEL Edward DAWSON
• 金额: $ 6.48万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-01 至 1993-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3386235
• 关键词: attention; autonomic nervous system; cognition; disease /disorder classification; disease /disorder proneness /risk; galvanic skin response; human subject; mental disorder diagnosis; neural information processing; orientation; schizophrenia; startle reaction

The specific aim of the proposed research is to explore the meaning of the electrodermal responder/ nonresponder distinction found among schizophrenics and those at risk for schizophrenia, specifically the implication that distinction has for differences in attentional dysfunctions. The existence of subgroups of schizophrenics who fail to show normal orienting responses (ORs), usually as indexed by the skin conductance response, is one of the most reliable autonomic nervous system abnormalities associated with schizophrenia. Since the OR is thought to reflect the allocation of attentional resources to the cognitive processing of stimuli, it reflects one of the most basic aspects of information processing. Because attentional theories of schizophrenia have long been entertained, abnormalities in the OR in this disorder and those at risk for it are inherently of interest. We will identify groups of electrodermal hyperactivated responders and hypoactivated nonresponders from among an existing well-diagnosed population of young, recent, onset schizophrenics and from among a large population of college students identified as at-risk for schizophrenia by their abnormal responses to standardized questionnaires (the Chapman Anhedonia, Perceptual Abberation, and Magical Ideation scales). All subjects will be presented with an orienting take in which certain stimuli are to be attended (OS+) and others are to be ignored (OS-). Allocation of both automatic (preattentive) and controlled information processing capacity of OS+ and OS-will be assessed through the use of two techniques, a probe reaction time stimulus technique and a startle blink stimulus technique. Nonresponder schizophrenics and at-risk subjects are predicted to show reduced ability to allocate processing capacity to the OS+, while responders are predicted to show difficulty in inhibiting allocation of attention to the OS-.

拟议研究的具体目的是探索 电致皮肤应答者/无应答者的区别 精神分裂症患者和精神分裂症高危人群，特别是 这种区别意味着注意力的不同 功能障碍。 精神分裂症患者中存在表现不正常的亚群 定向反应(OR)，通常以皮肤电导为指标 反应，是最可靠的自主神经系统之一 与精神分裂症有关的异常。因为手术室被认为 反映注意资源对认知加工的分配 对于刺激，它反映了信息最基本的方面之一 正在处理。因为精神分裂症的注意理论长期以来 娱乐，在这种障碍中的OR异常和那些有风险的 这本身就是一件有趣的事情。 我们将确定一组电皮肤过度激活的反应者和 来自现有诊断良好的低活性无应答者 年轻、新近发病的精神分裂症患者和来自一大批 被认定为精神分裂症高危人群的大学生人数 他们对标准化问卷的异常反应(查普曼 快感失调症、知觉失语和魔法想象量表)。全 受试者将被呈现一种定向的观点，其中特定的刺激 将被出席(OS+)，其他将被忽略(OS-)。分配给 自动(预注意)和受控信息处理 OS+和OS-的容量将通过使用两种技术进行评估， 探针式反应时刺激技术和惊恐眨眼刺激 技术。无反应精神分裂症患者和高危受试者被预测 显示将处理能力分配给OS+的能力降低，而 预计应答者将在抑制分配方面表现出困难 注意操作系统-。