ELECTRODERMAL DYSFUNCTIONS AND SCHIZOPHRENIA

皮肤电功能障碍和精神分裂症

• 批准号: 3486980
• 负责人: MICHAEL Edward DAWSON
• 金额: $ 8.96万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-01 至 1998-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3486980
• 关键词: attention; autonomic nervous system; cognition; disease /disorder classification; disease /disorder proneness /risk; galvanic skin response; human subject; mental disorder diagnosis; neural information processing; orientation; schizophrenia; startle reaction

This competing continuation application proposes two large projects to study the skin conductance orienting response (SCOR) and startle eye-blink modification (SEM) in order to better understand attentional and affective disorders in schizophrenic outpatients and putatively psychosis-prone college students. Attentional and affective dysfunctions have long been considered central deficits in schizophrenia, but have proven complex and difficult to measure. SCOR and SEM have been hypothesized to provide non- verbal, non-voluntary indices of basic attentional and affective processes; hence they may provide unique keys to understanding these dysfunctions in schizophrenia. The overall aim of the first project, which consists of a package of five experiments, is to evaluate the contribution of automatic and controlled cognitive processing in the mediation of SCOR and SEM. All five experiments in the first project require subjects to perform a difficult visual tracking primary task while SCOR and SEM are measured to either task-irrelevant stimuli or secondary task stimuli. The rationale is that if the primary tracking task is resource-demanding, then it will engage a considerable proportion of limited processing resources, leaving only a few resources to process concurrent stimuli. Thus, it will be possible to determine the effects of varying the available processing resources on SCOR and SEM in normal college students, putatively psychosis-prone college students, recent-onset schizophrenic patients, and demographically matched normal controls. The overall aim of the second proposed project, which consists of a package of three experiments, is to develop a new paradigm to separately evaluate attentional and affective modulation of SEM. These experiments will test theoretically derived hypotheses in groups of normal college students, anhedonic college students, recent-onset schizophrenic, patients, and demographically matched normal controls. These experiments will address issues regarding the affective specificity of emotional dysfunctions and will constitute the first test of affective modulation of SEM in schizophrenic patients.

这一竞争性的延续申请提出了两个大型项目， 研究皮肤电传导定向反应（SCOR）和惊吓眨眼 修正（SEM），以便更好地理解注意力和情感 精神分裂症门诊患者和有精神病倾向的 大学生长期以来，注意力和情感功能障碍 被认为是精神分裂症的中枢缺陷，但已被证明是复杂的， 难以衡量。SCOR和SEM已被假设为提供非 基本注意力和情感的语言、非自愿指数 过程;因此，它们可以提供理解这些过程的唯一密钥。 精神分裂症的功能障碍 第一个项目的总体目标包括五个方面， 实验，是为了评估自动和控制的贡献， 认知加工在SCOR和SEM的中介作用。所有五 第一个项目的实验要求受试者完成一个困难的 视觉跟踪主要任务，而SCOR和SEM被测量为 任务无关刺激或次要任务刺激。基本原理是 如果主要跟踪任务需要资源，那么它将使用 有限的处理资源的相当大的比例，只留下一个 处理并发刺激的资源很少。因此，将有可能 确定改变可用处理资源对 师范大学生抑郁性精神病易感人群的SCOR和SEM研究 大学生，近期发作的精神分裂症患者，以及人口统计学上的 匹配正常对照。 第二个拟议项目的总体目标包括： 一揽子三个实验，是开发一个新的范式，分别 评估SEM的注意力和情感调节。这些实验 将在师范学院的小组中测试理论推导的假设 学生，快感缺失的大学生，新近发作的精神分裂症患者， 患者和人口统计学匹配的正常对照。这些实验 将解决有关情感的情感特异性的问题， 功能障碍，并将构成情感调节的第一个测试， 精神分裂症患者的SEM。