PSYCHOPHYSIOLOGY OF SCHIZOPHRENIA

精神分裂症的心理生理学

• 批准号: 6538233
• 负责人: MICHAEL Edward DAWSON
• 金额: $ 10.65万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6538233
• 关键词: attention; behavior prediction; behavioral /social science research tag; clinical research; cognition disorders; disease /disorder proneness /risk; galvanic skin response; human subject; magnetic resonance imaging; neural information processing; outpatient care; psychophysiology; relapse /recurrence; schizoid personality; schizophrenia; sensory mechanism; siblings; startle reaction

DESCRIPTION (adapted from applicant's abstract): The overall aims of this proposed Research Career Award (K02) are to provide time for the PI to: (1) engage in an interdisciplinary, multi-site program of research on the psychophysiology of schizophrenia and (2) gain additional knowledge and skills in order to better integrate cognitive science, clinical science and neuroscience. More specifically, electrodermal activity and prepulse inhibition (PPI) of the startle eyeblink reflex will be measured in four sets of research projects at three different sites to test predictions derived from a vulnerability-stress model of schizophrenia. The first project investigates whether changes in electrodermal activity can help in the prediction of symptomatic exacerbation/relapse in schizophrenia patients. The second project examines whether schizophrenia PPI deficits are due to dysfunctions in automatic processes, controlled processes, or both. The third project tests whether PPI impairments demonstrated in both passive and attentionally active paradigms also occur in unaffected siblings of schizophrenia patients. The fourth project explores whether abnormalities in brain structures are related to electrodermal and PPI anomalies in schizophrenia patients and schizotypal individuals. In addition to these four research projects, the K02 will permit the PI to receive formal and informal training in techniques and principles of clinical science and neuroscience.

描述（改编自申请人摘要）：本研究的总体目标

项目成果

A longitudinal analysis of eye tracking dysfunction and attention in recent-onset schizophrenia.

新发精神分裂症眼动追踪功能障碍和注意力的纵向分析。

• 发表时间: 1998
• 期刊: Psychophysiology.
• 作者: Yee,CM;Nuechterlein,KH;Dawson,ME
• 通讯作者: Dawson,ME

Effects of perceptual load on startle reflex modification at a long lead interval.

知觉负荷对长导联间隔下惊吓反射修正的影响。

• DOI: 10.1111/j.1469-8986.2006.00420.x
• 发表时间: 2006
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Thorne,GaryL;Dawson,MichaelE;Schell,AnneM
• 通讯作者: Schell,AnneM

Arousal, working memory, and conscious awareness in contingency learning.

应急学习中的唤醒、工作记忆和自觉意识。

• DOI: 10.1016/j.concog.2008.04.007
• 发表时间: 2008
• 期刊: Consciousness and cognition
• 影响因子: 2.4
• 作者: Cosand,LouiseD;Cavanagh,ThomasM;Brown,AshleyA;Courtney,ChristopherG;Rissling,AnthonyJ;Schell,AnneM;Dawson,MichaelE
• 通讯作者: Dawson,MichaelE

The varying time courses of attentional and affective modulation of the startle eyeblink reflex.

惊跳眨眼反射的注意力和情感调节的不同时间过程。

• DOI: 10.1111/j.1469-8986.1996.tb02365.x
• 发表时间: 1996
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Vanman,EJ;Boehmelt,AH;Dawson,ME;Schell,AM
• 通讯作者: Schell,AM

Discrete and continuous prepulses have differential effects on startle prepulse inhibition and skin conductance orienting.

离散和连续预脉冲对惊吓预脉冲抑制和皮肤电导定向有不同的影响。

• 发表时间: 2000
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Wynn,JK;Dawson,ME;Schell,AM
• 通讯作者: Schell,AM