MEG EVOKED FIELDS AND MEMORY IN CHILDREN

MEG 诱发儿童场和记忆

• 批准号: 2635542
• 负责人: DONALD C. ROJAS
• 金额: $ 7.48万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2635542
• 关键词: adolescence (12-20); age difference; auditory stimulus; behavioral /social science research tag; cerebral dominance; child psychology; clinical research; evoked potentials; gender difference; human subject; magnetoencephalography; middle childhood (6-11); psychoacoustics; short term memory

DESCRIPTION (Adapted from applicant's abstract): A number of disorders affecting the cognitive development of children are associated with short-term auditory memory impairments. These impairments can affect the development of attention, memory, language, and as a consequence affect achievement in later life. However, very little data have been reported concerning the normal maturation of short-term memory stores in childhood, especially with respect to the co-development of the physiological and anatomical substrates of those functions. Preliminary evidence from this laboratory concerning auditory sensory memory (echoic memory) have broad implications for the development of working memory. Maturational changes in working memory have been identified in previous research, but questions remain concerning the mechanisms driving the change. We hypothesize that developmental alterations in the persistence of echoic memory underlie the increased capacity of working memory. The long-term goal of the project is to better understand the development of early auditory memory, both in functional and structural terms, so that this knowledge may be applied to clinical disorders where dysfunction in these systems exist, such as developmental dyslexia. Using magnetoencephalographic and psychoacoustic methods, we propose to study the development of echoic memory duration in children. We hypothesize a significant decrease in the duration of echoic memory during the years spanning preadolescence and adolescence. We also believe that gender will be a mediating factor in the development of echoic memory, and hypothesize that females will mature than males. Further, consistent with our preliminary data we hypothesize that the right hemisphere echoic trace will change more rapidly than the left hemisphere trace. We will also use anatomical information from magnetic resonance imaging, combined with MEG source lateralization, to measure the location of the neural generators involved in echoic memory. We hypothesize that the cerebral asymmetries usually present in adult males will not be present before adolescence. To better understand the constraints which echoic memory duration places upon working memory, we will relate the two systems' development in our studies.

描述（改编自申请人的摘要）：多种疾病 影响儿童的认知发展与 短期听觉记忆障碍。 这些障碍会影响 注意力，记忆，语言和结果影响 后来的成就。 但是，很少有数据报告 关于童年短期内存存储的正常成熟， 特别是关于生理和 这些功能的解剖基板。 初步证据 实验室有关听觉感觉记忆（回声记忆）的实验室广泛 对工作记忆发展的影响。 成熟的变化 在先前的研究中已经确定了工作记忆，但是问题 保持有关推动变化的机制。 我们假设这一点 回声记忆持续性的发展改变是 增加工作记忆的能力。 该项目的长期目标是 为了更好地了解早期听觉记忆的发展 功能性和结构性术语，以便将这些知识应用于 存在这些系统中功能障碍的临床障碍，例如 发育阅读障碍。 使用磁脑摄影和心理声学方法，我们建议 研究儿童回声记忆持续时间的发展。 我们假设 多年来，回声记忆的持续时间大大减少 跨越前和青春期。 我们也相信性别会 成为回声记忆发展的中介因素，并假设 那个女性比男性成熟。 此外，与我们一致 初步数据我们假设右半球回声轨迹将 比左半球迹线更快地更改。 我们还将使用 来自磁共振成像的解剖信息与MEG结合 来源横向化，测量神经发电机的位置 参与回声记忆。 我们假设大脑不对称 通常在成年男性中存在于青春期之前。 到 更好地了解哪些回声记忆持续时间的约束 工作记忆，我们将在研究中将两个系统的发展联系起来。