EXERCISE AND BLOOD PRESSURE IN CHILDREN: A META-ANALYSIS

描述：（改编自研究者摘要）心脏病和 中风是美国第一和第三大死亡原因， 直接和间接成本估计为2590亿美元。约 5000万美国人患有高血压， 增加中风心脏病和肾衰竭的风险公 儿童和青少年时期的血压水平 长大成人虽然药物干预可以帮助控制升高的 儿童和青少年的血压，一场关于 药物干预的有效性，因为有害的副作用。作为 因此，人们对锻炼的兴趣越来越大， 维持适当血压水平的非药物方法 儿童和青少年。最近的文献综述综合了 使用“传统”方法的研究（按时间顺序排列， 描述研究，也许通过副主题），这可能会导致主观， 不可复制的结论因此， 影响，以及这些变量之间的关系，如主题 特点，实验设计质量，培养方案特点， 以及它们如何影响静息时收缩期和舒张期血液的变化 压力不清楚。在这个拟议的项目中，元分析方法 也将用于综合研究总体影响程度 运动干预相关变量之间的关系， 儿童和青少年的静息收缩压和舒张压。 荟萃分析是一种汇集不同研究结果的方法。这是一个 增加主要终点统计功效的定量方法 和亚组，解决研究不一致时的不确定性，改善估计 效应量，并回答在个体研究开始时没有提出的问题 审判到目前为止，还没有研究定量地综合了现有的 关于运动作为非药物干预的作用的文献 降低或控制静息收缩压和舒张压水平 在儿童和青少年中。因此，本研究的目的是利用 运动对静息收缩压影响的荟萃分析方法 以及儿童和青少年的舒张压。调查人员 声明该项目的结果将澄清 运动在降低老年人静息收缩压和舒张压中的作用 儿童和青少年。

DESCRIPTION: (Adapted from the Investigator's Abstract) Heart disease and stroke are the first and third leading causes of death in the United States, costing an estimated $259 billion in direct and indirect costs. Approximately 50 million Americans suffer from hypertension, a condition associated with increased risk for stroke, heart attack, and kidney failure. It is well established that blood pressure levels during childhood and adolescence track into adulthood. While pharmacologic intervention can help to control elevated blood pressure in children and adolescents, a debate continues over the efficacy of pharmacologic intervention because of deleterious side effects. As a result, there has been an increased interest in exercise as a nonpharmacologic approach for maintaining adequate blood pressure levels in children and adolescents. Recent reviews of literature have synthesized research using the "traditional" approach (chronologically arranging and describing the studies, perhaps by subtopic) which may result in subjective, nonreplicable conclusions. Consequently, the overall magnitude and direction of effect, as well as the relationships among such variables as subject characteristics, experimental design quality, training program characteristics, and how they contribute to changes in resting systolic and diastolic blood pressure are not clear. In this proposed project, the meta-analytic approach will be used to synthesize research on the overall magnitude of effect as well as the relationships among variables associated with exercise intervention and resting systolic and diastolic blood pressure in children and adolescents. Meta-analysis is a method of pooling the results of separate studies. It is a quantitative approach for increasing statistical power of primary end points and subgroups, resolving uncertainty when studies disagree, improving estimates of effect sizes, and answering questions not posed at the start of individual trials. To date, no study has quantitatively synthesized the existing literature regarding the role of exercise as a nonpharmacologic intervention in reducing or controlling resting systolic and diastolic blood pressure levels among children and adolescents. Thus, the purpose of this study is to use the meta-analytic approach to examine the effects of exercise on resting systolic and diastolic blood pressure in children and adolescents. The investigators state that the results of this project will provide clarification regarding the role of exercise in reducing resting systolic and diastolic blood pressure in children and adolescents.