EXERCISE AND BLOOD PRESSURE IN CHILDREN: A META-ANALYSIS

描述：(改编自《调查者摘要》)心脏病和 在美国，中风是第一和第三大死亡原因， 直接和间接成本估计为2590亿美元。大致 5000万美国人患有高血压，这种疾病与 增加中风、心脏病发作和肾衰竭的风险。这很好 确定了儿童和青春期的血压水平 进入成年期。而药物干预可以帮助控制升高 儿童和青少年的血压，关于血压的争论仍在继续 药物干预的效果，因为有有害的副作用。AS 因此，人们对锻炼的兴趣与日俱增 维持正常血压水平的非药物方法 儿童和青少年。最近的文献综述综合了 使用“传统”方法的研究(按时间顺序排列和 可能通过副主题来描述研究)，这可能导致主观的， 不可复制的结论。因此，总的规模和方向 影响，以及主体等变量之间的关系 特色、实验设计质量、培训方案特色、 以及它们如何影响静息状态下收缩和舒张压的变化 压力尚不清楚。在这个拟议的项目中，元分析方法 也将被用来综合对整体效应大小的研究 由于与运动干预相关的变量之间的关系 儿童和青少年的静息收缩和舒张压。 荟萃分析是一种汇集不同研究结果的方法。这是一个 提高主要终点统计能力的定量方法 和分组，解决研究不一致时的不确定性，改进估计 效果大小，以及回答不是在个人开始时提出的问题 审判。到目前为止，还没有研究定量地合成现有的 关于运动作为一种非药物干预的作用的文献 降低或控制静息收缩压和舒张压水平 在儿童和青少年中。因此，本研究的目的是使用 运动对静息收缩压影响的荟萃分析方法 儿童和青少年的舒张压。调查人员 声明，该项目的结果将澄清关于 运动对降低老年人静息收缩压和舒张压的作用 儿童和青少年。

DESCRIPTION: (Adapted from the Investigator's Abstract) Heart disease and stroke are the first and third leading causes of death in the United States, costing an estimated $259 billion in direct and indirect costs. Approximately 50 million Americans suffer from hypertension, a condition associated with increased risk for stroke, heart attack, and kidney failure. It is well established that blood pressure levels during childhood and adolescence track into adulthood. While pharmacologic intervention can help to control elevated blood pressure in children and adolescents, a debate continues over the efficacy of pharmacologic intervention because of deleterious side effects. As a result, there has been an increased interest in exercise as a nonpharmacologic approach for maintaining adequate blood pressure levels in children and adolescents. Recent reviews of literature have synthesized research using the "traditional" approach (chronologically arranging and describing the studies, perhaps by subtopic) which may result in subjective, nonreplicable conclusions. Consequently, the overall magnitude and direction of effect, as well as the relationships among such variables as subject characteristics, experimental design quality, training program characteristics, and how they contribute to changes in resting systolic and diastolic blood pressure are not clear. In this proposed project, the meta-analytic approach will be used to synthesize research on the overall magnitude of effect as well as the relationships among variables associated with exercise intervention and resting systolic and diastolic blood pressure in children and adolescents. Meta-analysis is a method of pooling the results of separate studies. It is a quantitative approach for increasing statistical power of primary end points and subgroups, resolving uncertainty when studies disagree, improving estimates of effect sizes, and answering questions not posed at the start of individual trials. To date, no study has quantitatively synthesized the existing literature regarding the role of exercise as a nonpharmacologic intervention in reducing or controlling resting systolic and diastolic blood pressure levels among children and adolescents. Thus, the purpose of this study is to use the meta-analytic approach to examine the effects of exercise on resting systolic and diastolic blood pressure in children and adolescents. The investigators state that the results of this project will provide clarification regarding the role of exercise in reducing resting systolic and diastolic blood pressure in children and adolescents.