EXERCISE AND BLOOD PRESSURE IN CHILDREN: A META-ANALYSIS

儿童运动与血压：荟萃分析

• 批准号: 6197502
• 负责人: George A Kelley
• 金额: $ 15.25万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6197502
• 关键词: adolescence (12-20); blood pressure; cardiovascular disorder epidemiology; cardiovascular disorder prevention; child (0-11); clinical research; exercise; human data; human therapy evaluation; hypertension; meta analysis

DESCRIPTION: (Adapted from the Investigator's Abstract) Heart disease and stroke are the first and third leading causes of death in the United States, costing an estimated $259 billion in direct and indirect costs. Approximately 50 million Americans suffer from hypertension, a condition associated with increased risk for stroke, heart attack, and kidney failure. It is well established that blood pressure levels during childhood and adolescence track into adulthood. While pharmacologic intervention can help to control elevated blood pressure in children and adolescents, a debate continues over the efficacy of pharmacologic intervention because of deleterious side effects. As a result, there has been an increased interest in exercise as a nonpharmacologic approach for maintaining adequate blood pressure levels in children and adolescents. Recent reviews of literature have synthesized research using the "traditional" approach (chronologically arranging and describing the studies, perhaps by subtopic) which may result in subjective, nonreplicable conclusions. Consequently, the overall magnitude and direction of effect, as well as the relationships among such variables as subject characteristics, experimental design quality, training program characteristics, and how they contribute to changes in resting systolic and diastolic blood pressure are not clear. In this proposed project, the meta-analytic approach will be used to synthesize research on the overall magnitude of effect as well as the relationships among variables associated with exercise intervention and resting systolic and diastolic blood pressure in children and adolescents. Meta-analysis is a method of pooling the results of separate studies. It is a quantitative approach for increasing statistical power of primary end points and subgroups, resolving uncertainty when studies disagree, improving estimates of effect sizes, and answering questions not posed at the start of individual trials. To date, no study has quantitatively synthesized the existing literature regarding the role of exercise as a nonpharmacologic intervention in reducing or controlling resting systolic and diastolic blood pressure levels among children and adolescents. Thus, the purpose of this study is to use the meta-analytic approach to examine the effects of exercise on resting systolic and diastolic blood pressure in children and adolescents. The investigators state that the results of this project will provide clarification regarding the role of exercise in reducing resting systolic and diastolic blood pressure in children and adolescents.

描述：（改编自研究者摘要）心脏病和 中风是美国第一和第三大死因， 直接和间接成本估计为 2,590 亿美元。大约 5000 万美国人患有高血压，这是一种与以下疾病相关的疾病 中风、心脏病和肾衰竭的风险增加。很好 确定儿童期和青春期的血压水平 进入成年期。虽然药物干预可以帮助控制升高 关于儿童和青少年血压的争论仍在继续 由于有害副作用而导致药物干预的功效。作为 结果，人们对锻炼的兴趣日益浓厚 维持适当血压水平的非药物方法 儿童和青少年。最近的文献综述综合了 使用“传统”方法（按时间顺序排列和 描述研究，也许是通过子主题）这可能会导致主观， 不可复制的结论。因此，总体的大小和方向 效果，以及主题等变量之间的关系 特点、实验设计质量、培训项目特点、 以及它们如何影响静息收缩压和舒张压的变化 压力不清楚。在这个拟议的项目中，元分析方法 也将用于综合对总体影响程度的研究 作为与运动干预相关的变量之间的关系 儿童和青少年的静息收缩压和舒张压。 荟萃分析是一种汇总单独研究结果的方法。它是一个 提高主要终点统计功效的定量方法 和亚组，解决研究不一致时的不确定性，改进估计 效应大小，并回答个人开始时未提出的问题 试验。迄今为止，还没有研究对现有的 关于运动作为非药物干预的作用的文献 降低或控制静息收缩压和舒张压水平 儿童和青少年之间。因此，本研究的目的是利用 荟萃分析方法检查运动对静息收缩压的影响 以及儿童和青少年的舒张压。调查人员 指出该项目的结果将澄清 运动在降低静息收缩压和舒张压方面的作用 儿童和青少年。