Aerobic Exercise and Cholesterol: A Meta-Analysis

有氧运动和胆固醇：荟萃分析

• 批准号: 6663851
• 负责人: George A Kelley
• 金额: $ 19.83万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-25 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6663851
• 关键词: aerobic exercise; blood lipoprotein; cardiovascular disorder; cardiovascular disorder risk; cardiovascular disorder therapy; cerebrovascular disorders; cholesterol; clinical research; health science research analysis /evaluation; human subject; human therapy evaluation; mathematical model; meta analysis; statistics /biometry

DESCRIPTION (provided by applicant): Heart disease and cerebrovascular disease are the first and third leading causes of mortality in the United States, accounting for 887,000 (38 percent) of all deaths annually. The total direct and indirect costs associated with cardiovascular disease have been estimated at $326.6 billion each year. Abnormal lipid and lipoprotein levels, a common problem among more than 100 million (about 20 percent), of American adults, have been associated with an increased risk for heart attack and cerebrovascular disease. While pharmacologic intervention can help to control abnormal lipid and lipoprotein levels in adults, a debate continues over the efficacy of pharmacologic interventions because of deleterious side effects and costs. Aerobic exercise is a low-cost, nonpharmacologic intervention that has few side effects and is available to most of the general public. Consequently, there has been a continued interest in aerobic exercise as a nonpharmacologic approach for maintaining adequate lipid and lipoprotein levels in adults Recent reviews of literature on this topic have synthesized research using the "traditional" approach (chronologically arranging and describing the studies, perhaps by subtopic), which may result in subjective, nonreplicable conclusions. Consequently, the overall magnitude and direction of effect, as well as the relationships among such variables as subject characteristics, experimental design quality, training program characteristics, and how they contribute to changes in lipid and lipoprotein levels, is not clear. Meta-analysis is a method of pooling the results of separate studies. It is a quantitative approach for increasing statistical power of primary end points and subgroups, resolving uncertainty when studies disagree, improving estimates of effect sizes, and answering questions not posed at the start of individual trials. To date, no recent study has conducted a detailed, quantitative synthesis of the existing literature regarding the role of aerobic exercise as a nonpharmacologic intervention/or improving lipid and lipoprotein levels in adults. In this proposed project, the meta-analytic approach will be used to synthesize research on the overall magnitude of effect as well as the relationships among variables associated with aerobic exercise and lipid and lipoprotein levels in adults.

描述（由申请人提供）：心脏病和脑血管病 是美国第一和第三大死亡原因， 占每年所有死亡人数的887，000人（38%）。总直接 和与心血管疾病相关的间接成本已经被估计， 每年3266亿美元。血脂和脂蛋白水平异常， 在超过1亿（约20%）的美国成年人中， 与心脏病发作的风险增加有关， 脑血管疾病虽然药物干预可以帮助控制 成人血脂和脂蛋白水平异常，关于 药物干预的有效性，因为有害的副作用， 成本有氧运动是一种低成本的非药物干预， 副作用少，大多数公众都可以使用。因此，委员会认为， 有氧运动作为一种非药物疗法， 维持成人适当脂质和脂蛋白水平的方法最近 关于这一主题的文献综述综合了使用 “传统”方法（按时间顺序排列和描述研究， 也许是副主题），这可能会导致主观的，不可复制的 结论.因此，影响的总体幅度和方向， 以及受试者特征等变量之间的关系， 实验设计质量，培训计划的特点，以及他们如何 导致脂质和脂蛋白水平的变化，尚不清楚。 荟萃分析是一种汇集不同研究结果的方法。这是一个 增加主要终点统计功效的定量方法 和亚组，解决研究不一致时的不确定性，改善估计 效应量，并回答在个体研究开始时没有提出的问题 审判到目前为止，还没有一项新的研究进行了详细的定量分析。 综合现有文献关于有氧运动的作用， 非药物干预/或改善血脂和脂蛋白水平 成年人了在这个拟议的项目中，元分析方法将用于 综合研究的整体规模的影响，以及 与有氧运动和血脂相关的变量之间的关系 成人的脂蛋白水平。