Exercise and Anxiety in Adults with Arthritis: An IVHet Meta-Analysis

成人关节炎患者的运动和焦虑：IVHet 荟萃分析

• 批准号: 9236757
• 负责人: George A Kelley
• 金额: $ 17.64万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9236757
• 关键词: Address; Adult; Aerobic Exercise; Age Factors; Anxiety; Arthritis; Body mass index; Communities; Comorbidity; Conflict (Psychology); Data Aggregation; Degenerative polyarthritis; Effectiveness; Exercise; Fibromyalgia; General Population; Goals; Health; Health Professional; Institutes; Intervention; Intervention Studies; Intervention Trial; Literature; Mental Depression; Meta-Analysis; Mission; Modeling; Musculoskeletal Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Outcome; Pain; Pain quality; Participant; Persons; Physical Function; Population; Prevalence; Public Health; Quality of life; Randomized; Randomized Controlled Trials; Recommendation; Research; Research Personnel; Rheumatism; Rheumatoid Arthritis; Time; Training; United States; Work; anxiety symptoms; base; cost; depressive symptoms; effective therapy; evidence based guidelines; exercise intervention; experience; improved; prevent; primary outcome; programs; public health relevance; secondary outcome; skin disorder; strength training; success; systematic review; time use; treatment effect

PROJECT SUMMARY/ABSTRACT The prevalence of anxiety has been shown to be almost twice as high as depression among adults with arthritis and other rheumatic diseases (AORD). One potential nonpharmacologic approach for reducing anxiety in adults with AORD is exercise, an intervention that is generally safe and appropriate for most persons with various types of AORD. However, the overall treatment effect as well as treatment-covariate interactions from different studies addressing the effects of community-based exercise on anxiety in adults with AORD has never been elucidated at the meta-analytic level. This is problematic because it prevents health professionals from providing evidence-based recommendations regarding a low-cost, readily available, nonpharmacologic intervention that is available to the vast majority of the general public. This proposed project aims to fill these gaps. Using a recently developed meta-analytic approach that has been shown to be more valid than existing approaches, the overall objective of this two- year investigator-initiated R01 competitive renewal application is to examine the randomized controlled trial literature over an approximate 30 year period in order to determine the effects of community-deliverable exercise (aerobic, strength, or both) on anxiety in adults with osteoarthritis, rheumatoid arthritis and fibromyalgia, the three types of AORD in which the largest number of randomized controlled exercise intervention trials are available. The specific aims of this project are to (1) determine the overall effects of community-deliverable exercise on anxiety in adults with selected types of AORD, and (2) identify those factors associated with community-deliverable exercise-induced changes in anxiety among adults with selected types of AORD. The results of this first-ever project, conducted by a team of experienced investigators with proven success in exercise, meta-analysis, and arthritis, will provide evidence-based recommendations regarding the effects of community-deliverable exercise on anxiety in adults with osteoarthritis, rheumatoid arthritis and fibromyalgia. This will be new and important information regarding the treatment of adults with selected types of arthritis at the community level, an approach that has the potential for the greatest reach in fulfilling part of the mission of NIAMS, that is, the “treatment of arthritis and musculoskeletal and skin diseases”.

项目总结/摘要 焦虑症的患病率几乎是抑郁症的两倍， 患有关节炎和其他风湿性疾病（AORD）的成年人。一种潜在的非药理学 减少成人AORD焦虑的方法是锻炼，这种干预通常是 安全和适合大多数人与各种类型的AORD。但整体 来自不同研究的治疗效应以及治疗-协变量相互作用， 社区锻炼对成人AORD患者焦虑的影响尚未阐明 在元分析的层面上。这是有问题的，因为它阻止了卫生专业人员 提供关于低成本、容易获得、 非药物干预，这是提供给广大公众。这 该项目旨在填补这些空白。使用最近开发的荟萃分析方法 这已经被证明是比现有的方法更有效，这两个的总体目标- 一年后，制药商发起的R 01竞争性更新申请将检查随机化 在大约30年的时间内，对照试验文献，以确定 社区可交付的运动（有氧，力量，或两者兼而有之）对成人焦虑的影响 骨关节炎、类风湿性关节炎和纤维肌痛，这三种类型的AORD中， 最大数量的随机对照运动干预试验。具体 本项目的目标是：（1）确定社区交付练习的总体效果， 成人中的焦虑与选定类型的AORD，（2）确定这些因素与 社区可交付的运动引起的焦虑在成年人中的变化， 奥德。这是有史以来第一个项目的结果，由一个经验丰富的调查小组进行， 在运动，荟萃分析和关节炎方面取得了成功，将提供基于证据的 关于社区运动对成年人焦虑的影响的建议 骨关节炎类风湿性关节炎和纤维肌痛这将是新的和重要的 关于在社区治疗选定类型关节炎的成人的信息 水平，一种方法，有潜力的最大范围履行部分的使命， NIAMS，即“治疗关节炎、肌肉骨骼和皮肤疾病”。