New Protocols for the Chemical Synthesis of Biologically Relevant Systems

生物相关系统化学合成的新方案

• 批准号: DP150101947
• 负责人: Prof Martin Banwell
• 金额: $ 49.01万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150101947
• 关键词: New; Protocols; Chemical; Synthesis; Biologically

Enzyme- and metal-catalysed processes will be developed and exploited for the purpose of establishing concise syntheses of biologically active and otherwise inaccessible natural products and their analogues. The range of structures to be targeted is structurally diverse and these have the potential to act as agrochemicals and/or as therapeutic agents for the treatment of a range of disease states in mammals including bacterial and viral infections, neuro-degenerative conditions and impaired cognitive function. Anti-angiogenic compounds that control otherwise unregulated cellular growth may also arise from these studies. The generation of new, homochiral metabolites for use in chemoenzymatic synthesis should also emerge from this project.

将开发和利用酶催化和金属催化工艺，以建立生物活性和其他难以获得的天然产物及其类似物的简洁合成。待靶向的结构的范围在结构上是多样的，并且这些具有用作农用化学品和/或用作治疗剂的潜力，用于治疗哺乳动物中的一系列疾病状态，包括细菌和病毒感染、神经变性病症和认知功能受损。这些研究也可能产生控制否则不受调节的细胞生长的抗血管生成化合物。用于化学酶促合成的新的纯手性代谢产物的产生也应该从这个项目中出现。