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New Protocols for the Chemical Synthesis of Biologically Relevant Systems

New Protocols for the Chemical Synthesis of Biologically Relevant Systems
生物相关系统化学合成的新方案
批准号：
DP150101947
负责人：
Prof Martin Banwell
金额：
$49.01万
依托单位：
The Australian National University
依托单位国家：
澳大利亚
项目类别：
Discovery Projects
财政年份：
2015
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2015-01-01 至 2019-12-31
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/DP150101947
关键词：
NewProtocolsChemicalSynthesisBiologically

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英文摘要
Enzyme- and metal-catalysed processes will be developed and exploited for the purpose of establishing concise syntheses of biologically active and otherwise inaccessible natural products and their analogues. The range of structures to be targeted is structurally diverse and these have the potential to act as agrochemicals and/or as therapeutic agents for the treatment of a range of disease states in mammals including bacterial and viral infections, neuro-degenerative conditions and impaired cognitive function. Anti-angiogenic compounds that control otherwise unregulated cellular growth may also arise from these studies. The generation of new, homochiral metabolites for use in chemoenzymatic synthesis should also emerge from this project.
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Harnessing strain for chemical synthesis: The cyclopropane angle
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    $32.61万
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    2017
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    Prof Martin Banwell
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    The Australian National University
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    $6.33万
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    2011
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    Prof Martin Banwell
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    The Australian National University
Synthesis and Biological Evaluation of Australian Sponge Metabolites
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    DP110103021
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    2011
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    Prof Martin Banwell
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    The Australian National University
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