New Protocols for the Chemical Synthesis of Biologically Relevant Systems

将开发和利用酶催化和金属催化的工艺，以建立具有生物活性和以其他方式难以获得的天然产物及其类似物的简明合成。要针对的结构范围是多样化的，这些结构有可能作为农用化学品和/或作为治疗哺乳动物一系列疾病状态的治疗剂，包括细菌和病毒感染、神经退行性疾病和认知功能受损。控制细胞生长的抗血管生成化合物也可能从这些研究中产生。用于化学酶合成的新的同手性代谢物的产生也应该从这个项目中出现。

Enzyme- and metal-catalysed processes will be developed and exploited for the purpose of establishing concise syntheses of biologically active and otherwise inaccessible natural products and their analogues. The range of structures to be targeted is structurally diverse and these have the potential to act as agrochemicals and/or as therapeutic agents for the treatment of a range of disease states in mammals including bacterial and viral infections, neuro-degenerative conditions and impaired cognitive function. Anti-angiogenic compounds that control otherwise unregulated cellular growth may also arise from these studies. The generation of new, homochiral metabolites for use in chemoenzymatic synthesis should also emerge from this project.