Harnessing strain for chemical synthesis: The cyclopropane angle

利用应变进行化学合成：环丙烷角

• 批准号: DP170100926
• 负责人: Prof Martin Banwell
• 金额: $ 32.61万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100926
• 关键词: Harnessing; strain; chemical; synthesis; cyclopropane

This project aims to develop new reaction pathways of cyclopropanes, the smallest and most strained monocyclic ring systems, but which are also stable and easily prepared. Cyclopropanes have unique capacities to serve as highly effective building blocks in the synthesis of a wide range of otherwise difficult to access and biologically active molecular frameworks. This project will use cyclopropanes to rapidly assemble biologically active systems, especially pharmaceutically or agrochemically valuable natural products and relevant analogues.

该项目旨在开发环丙烷的新反应途径，环丙烷是最小和最紧张的单环系统，但也是稳定和容易制备的。环丙烷具有独特的能力，可以作为高效的构建块，用于合成一系列否则难以获得和具有生物活性的分子框架。该项目将使用环丙烷快速组装生物活性体系，特别是具有药学或农化价值的天然产物和相关类似物。