TRANSFER OF ORGANELLE GENES TO THE NUCLEUS
细胞器基因转移至细胞核
基本信息
- 批准号:2838513
- 负责人:
- 金额:$ 28.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1989
- 资助国家:美国
- 起止时间:1989-09-01 至 2000-11-30
- 项目状态:已结题
- 来源:
- 关键词:Arabidopsis Chlorophyta DNA directed RNA polymerase angiosperms biochemical evolution cell nucleus chloroplasts cytochrome oxidase cytogenetics developmental genetics gene expression gene mutation genetic transcription genome mitochondria mitochondrial DNA molecular cloning nucleic acid hybridization nucleic acid sequence organelles plant genetics plant morphology polymerase chain reaction protein structure function
项目摘要
The study of organelle genes and genomes is essential to our
understanding of eukaryotic cellular and molecular biology. The
proper functioning of organelles in all eukaryotic cells involves a
precise cooperation between nuclear and organellar genetic systems.
Defects in this functioning have direct consequences for human
health, as is evident from the recent explosion of reports on
mitochondrially inherited diseases. This proposal addresses two
fundamental questions in the genetic coevolution of the eukaryotic
cell: l) How are organelle genes functionally transferred to the
nucleus and what are the consequences of these genetic relocations?
2) To what extent can organelle mutation rates change radically,
either across the whole genome or for a specific set of genes, and
what are the underlying causes and consequences of this change?
First, several cases of recent gene transfer will be explored in order
to l) fully develop the coxII transfer as a paradigmatic case of "gene
transfer caught in the act", i.e., the elaboration of a
transcompartmental gene-family that is actively sorting out gene
function between the mitochondrion and the nucleus; 2) determine
whether gene transfer or gene substitution events have occurred
across all three genetic compartments for the ribosomal protein gene
rps7; 3) determine whether chloroplast genes are transferred to the
nucleus via RNA intermediates; 4) test the hypothesis that nuclear
spliceosomal introns can evolve from organelle-derived group II
introns; and 5) determine whether the mitochondrial genome is
fundamentally dispensable or required, perhaps because it encodes
two key, unimportable respiratory proteins.
Second, we will accurately measure the extraordinary elevation in
mutation rate of the mitochondrial genome in Pelargonium,
determine whether its lack of RNA editing reflects wholesale genome
retroprocessing, and investigate a possible mechanistic link between
these two features. We will also document the full extent of the
highly accelerated evolution that is specific to the four chloroplast
genes encoding RNA polymerase, as well as search for associated
changes in chloroplast promoter and RNA polymerase usage.
细胞器基因和基因组的研究对我们的研究至关重要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JEFFREY D PALMER其他文献
JEFFREY D PALMER的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JEFFREY D PALMER', 18)}}的其他基金
Genomic studies of chimeric mitochondria in cybrids from Solanaceae
茄科杂种嵌合线粒体的基因组研究
- 批准号:
7911843 - 财政年份:2009
- 资助金额:
$ 28.52万 - 项目类别:
Genomic studies of chimeric mitochondria in cybrids from Solanaceae
茄科杂种嵌合线粒体的基因组研究
- 批准号:
7694547 - 财政年份:2009
- 资助金额:
$ 28.52万 - 项目类别:
Genomic studies of chimeric mitochondria in cybrids from Solanaceae
茄科杂种嵌合线粒体的基因组研究
- 批准号:
8076901 - 财政年份:2009
- 资助金额:
$ 28.52万 - 项目类别:
Horizontal Gene Transfer in Multicellular Eukaryotes
多细胞真核生物中的水平基因转移
- 批准号:
6875514 - 财政年份:2005
- 资助金额:
$ 28.52万 - 项目类别:
Horizontal Gene Transfer in Multicellular Eukaryotes
多细胞真核生物中的水平基因转移
- 批准号:
7009271 - 财政年份:2005
- 资助金额:
$ 28.52万 - 项目类别:
Horizontal Gene Transfer in Multicellular Eukaryotes
多细胞真核生物中的水平基因转移
- 批准号:
7174292 - 财政年份:2005
- 资助金额:
$ 28.52万 - 项目类别:
Horizontal Gene Transfer in Multicellular Eukaryotes
多细胞真核生物中的水平基因转移
- 批准号:
7348367 - 财政年份:2005
- 资助金额:
$ 28.52万 - 项目类别:
相似海外基金
Development of odor sensing culture method for microalga Scenedesmus sp. (Chlorophyta) as novel agricultural crops
微藻栅藻气味传感培养方法的开发。
- 批准号:
21K19171 - 财政年份:2021
- 资助金额:
$ 28.52万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Investigation on the distribution of alkylglycerolipids in Chlorophyta
烷基甘油脂在绿藻中分布的研究
- 批准号:
18K05827 - 财政年份:2018
- 资助金额:
$ 28.52万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Polyols in the green algal class Trebouxiophyceae (Chlorophyta) - biochemical profiling and molecular characterization of biosynthetic mechanisms for a phylogenetic-(chemo)taxonomical classification
绿藻类 Trebouxiophyceae(绿藻门)中的多元醇 - 系统发育(化学)分类学分类的生物合成机制的生化分析和分子表征
- 批准号:
204541918 - 财政年份:2011
- 资助金额:
$ 28.52万 - 项目类别:
Research Grants
Structure and function of the contractile vacuoles of Chlamydomonas reinhardtii (Chlorophyta)
莱茵衣藻(绿藻门)收缩液泡的结构和功能
- 批准号:
158148367 - 财政年份:2009
- 资助金额:
$ 28.52万 - 项目类别:
Research Grants
Systematics of the Subaerial Green Algal Order Trentepohliales (Chlorophyta, Ulvophyceae) Based on Morphological and Molecular Evidence
基于形态学和分子证据的陆生绿藻目 Trentepohliales(绿藻门、Ulvophyceae)的系统学
- 批准号:
0542924 - 财政年份:2006
- 资助金额:
$ 28.52万 - 项目类别:
Standard Grant
PEET: Integrating Classical with Phylogenetic Taxonomic Treatments in Five Genera of Coccoid Green Algae (Chlorophyta)
PEET:将经典与系统发育分类学处理相结合,用于球状绿藻(绿藻)的五个属
- 批准号:
0529737 - 财政年份:2005
- 资助金额:
$ 28.52万 - 项目类别:
Continuing Grant
DISSERTATION RESEARCH: Systematics, Colony Form Evolution and Phenotypic Plasticity within the Family Hydrodictyaceae (Sphaeropleales, Chlorophyta)
论文研究:水藻科(Sphaeropleales、绿藻门)内的系统学、菌落形态进化和表型可塑性
- 批准号:
0407752 - 财政年份:2004
- 资助金额:
$ 28.52万 - 项目类别:
Standard Grant
Gattungs- und Artkonzept bei Chlorella und Micractinium (Chlorophyta, Chlorellaceae): Genotyp versus phaenotypsicher Variabilität unter dem Einfluss von Kairomonen
小球藻和小球藻(绿藻门、小球藻科)的属和种概念:利好素影响下的基因型与表型某些变异
- 批准号:
5370188 - 财政年份:2002
- 资助金额:
$ 28.52万 - 项目类别:
Research Grants
Art- und Gattungskonzept innerhalb der Volvocales (Chlorophyceae, Chlorophyta)
团藻目(绿藻纲、绿藻门)内的种和属概念
- 批准号:
5355017 - 财政年份:2001
- 资助金额:
$ 28.52万 - 项目类别:
Research Grants
Towards a Monograph of the Ulvellaceae (Ulvophyceae, Chlorophyta)and related green algae
走向 Ulvellaceae(Ulvophyceae、Chlorophyta)及相关绿藻专着
- 批准号:
0075601 - 财政年份:2000
- 资助金额:
$ 28.52万 - 项目类别:
Continuing Grant