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DROSOPHILA & TUBULIN RING COMPLEX (ANDTURC)

DROSOPHILA & TUBULIN RING COMPLEX (ANDTURC)
果蝇
批准号：
6019332
负责人：
Yixian Zheng
金额：
$19.24万
依托单位：
CARNEGIE INSTITUTION OF WASHINGTON, D.C.
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-09-30 至 2002-08-31
来源：
https://reporter.nih.gov/project-details/6019332
关键词：
cell cycle centrosome electron microscopy microtubule associated protein microtubules molecular cloning protein structure function

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DESCRIPTION: The long-term goal of this research is to understand how centrosomes in animal cells nucleate microtubules and how this nucleating activity is regulated by cell-cycle and developmental processes. The protein complex to be used in this study is the recently identified gamma-tubulin ring complex (gamma-TuRC) which can nucleate and bind to the minus ends of tits nucleated microtubules in vitro. Based on a number of lines of evidence it is hypothesized that the gamma-TuRC is the major microtubule nucleator at the centrosomes. The gamma-TuRC consists of gamma tubulin and at least five currently unidentified proteins (p183, p151, p98, p82 and p75s). The four aims of this proposal are to: 1) clone and biochemically characterize the currently unknown proteins in the gamma-TuRC; 2) elucidate the structural organization of gamma-TuRC; 3)reconstitute functional gamma TuRC in vitro; and 4)determine the detailed functions of the gamma-TuRC.
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The Mechanism of Spindle Assembly and Chromosome Alignment
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The Effects of Ethanol on Microtubules during Mouse Pre-implantation Development
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