Unifying mechanisms of innate immunity signaling in animals and plants

动物和植物先天免疫信号传导的统一机制

• 批准号: FL180100109
• 负责人: Prof Bostjan Kobe
• 金额: $ 195.52万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL180100109
• 关键词: Unifying; mechanisms; innate; immunity; signaling

This project aims to improve our understanding of innate immunity, the first line of defense against pathogens in diverse organisms. Innate immune pathways are key to a range of pathological states in animals, and provide plants with resistance to the diseases that account for 15% of crop losses. This project will generate knowledge, through characterising mechanisms of cell signalling for mammalian and plant innate immunity. The outcomes will include a unified signalling model, and form the foundation for a range of applications in human biology and agriculture, such as the development of durable and effective resistance in crops.

该项目旨在提高我们对先天免疫的理解，先天免疫是不同生物体对抗病原体的第一道防线。先天免疫途径是动物一系列病理状态的关键，并为植物提供了对占作物损失15%的疾病的抵抗力。该项目将通过描述哺乳动物和植物先天免疫的细胞信号传导机制来产生知识。这些成果将包括一个统一的信号模型，并为人类生物学和农业的一系列应用奠定基础，例如在作物中开发持久有效的抗性。