Automated high resolution and high contrast cryo -TEM for three-dimensional structural biology
Automated high resolution and high contrast cryo -TEM for three-dimensional structural biology
批准号:
LE180100179
负责人:
Prof Bostjan Kobe
金额:
$212.64万
依托单位国家:
澳大利亚
项目类别:
Linkage Infrastructure, Equipment and Facilities
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-03-29 至 2019-12-31
中文摘要
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英文摘要
This project aims to establish a facility in automated, single-particle cryo-TEM and cryo-TEM tomography (Titan Krios) that will enable atomic and molecular structure research and three-dimensional subcellular and cellular imaging. The project will span all multiscale cryo-TEM modalities from the visualisation of cells, membranes and macromolecular complexes, through to near-atomic-resolution protein structure determination. Cryo-single particle analysis and tomography are recognised as revolutionary technologies in molecular structural biology and powerful enablers of future ground-breaking discovery. The project will deliver significant competitive advantage for Australia in leading-edge structure-based research, drug discovery, new opportunities for applied research and development, and showcasing science to the public.
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财政年份:2019
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Molecular mechanisms of signalling by plant immune receptors
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财政年份:2019
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Structural biology and therapeutic targeting of proteins involved in infection and immunity
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批准号:nhmrc : GNT1110971
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项目类别:Research Fellowships
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资助金额:$75.33万
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财政年份:2016
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负责人:Prof Bostjan Kobe
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依托单位:
Structural biology and therapeutic targeting of proteins involved in infection and immunity
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批准号:nhmrc : 1110971
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项目类别:Research Fellowships
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资助金额:$51.94万
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财政年份:2016
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Molecular mechanism of action of plant immune receptors
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财政年份:2016
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Protein glycan interactions in infectious diseases.
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批准号:nhmrc : GNT1071659
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资助金额:$879.58万
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财政年份:2015
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负责人:Prof Bostjan Kobe
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依托单位:
Protein glycan interactions in infectious diseases.
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批准号:nhmrc : 1071659
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项目类别:Program Grants
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资助金额:$612.27万
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财政年份:2015
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负责人:Prof Bostjan Kobe
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依托单位:
Understanding the molecular function of plant disease resistance proteins, pathogen effectors and their interaction to protect Australian agriculture
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批准号:DP120100685
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项目类别:Discovery Projects
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资助金额:$26.52万
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财政年份:2012
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负责人:Prof Bostjan Kobe
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依托单位:
Structural biology of infection and immunity
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批准号:nhmrc : 1003325
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项目类别:Research Fellowships
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资助金额:$44.31万
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财政年份:2011
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负责人:Prof Bostjan Kobe
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Molecular basis of the interaction between plant disease resistance proteins and pathogen avirulence proteins
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批准号:DP0984827
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项目类别:Discovery Projects
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资助金额:$20.8万
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财政年份:2009
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负责人:Prof Bostjan Kobe
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依托单位:
Functional and structural characterisation of Defective embryo and meristems (Dem) proteins involved in plant development.
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批准号:DP0559710
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项目类别:Discovery Projects
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资助金额:$18.02万
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财政年份:2005
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负责人:Prof Bostjan Kobe
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依托单位:
New approaches to functional and structural genomics
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批准号:FF0561371
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项目类别:Federation Fellowships
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资助金额:$108.92万
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财政年份:2005
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负责人:Prof Bostjan Kobe
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依托单位:
Structural biology
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批准号:nhmrc : 252736
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项目类别:NHMRC Research Fellowships
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资助金额:$30.21万
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财政年份:2003
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负责人:Prof Bostjan Kobe
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依托单位:
Molecular basis of dengue virus-induced fusion
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批准号:nhmrc : 252739
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项目类别:NHMRC Project Grants
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资助金额:$27.36万
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财政年份:2003
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负责人:Prof Bostjan Kobe
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依托单位:
Structural studies of plant disease resistance proteins
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批准号:DP0208353
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项目类别:Discovery Projects
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资助金额:$22.21万
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财政年份:2002
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负责人:Prof Bostjan Kobe
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依托单位:
Structural characterisation of phosphopeptide recognition by FHA domains
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批准号:nhmrc : 143013
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项目类别:NHMRC Project Grants
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资助金额:$17.14万
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财政年份:2001
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负责人:Prof Bostjan Kobe
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依托单位:
Structural characterisation of nuclear localisation signal-receptor recognition
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批准号:nhmrc : 991554
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项目类别:NHMRC Project Grants
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资助金额:$13.37万
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财政年份:1999
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负责人:Prof Bostjan Kobe
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依托单位:
国内基金
海外基金
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