Molecular mechanisms of signalling by plant immune receptors

植物免疫受体信号传导的分子机制

• 批准号: DP190102526
• 负责人: Prof Bostjan Kobe
• 金额: $ 37.8万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-03-14 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102526
• 关键词: Molecular; mechanisms; signalling; plant; immune

This project aims to understand how resistance proteins function and to find new sources of these proteins. Plant diseases account for 15% loss of global crop production, representing a threat to food security. Fungicides, one key form of protection, represent environmental concerns. The other key form of protection corresponds to resistance gene breeding, which is limited by lengthy breeding processes, restricted choice of genes from sexually compatible species and short effective time spans in the field. Building on previous research, this project aims to characterise the molecular basis of the Toll/interleukin-1 receptor domain-mediated nicotinamide adenine dinucleotide (NAD+) cleavage and the structural architecture of plant NLR complexes. This knowledge will support the long-term objective of protecting crops from pathogens.

该项目旨在了解抗性蛋白的功能，并寻找这些蛋白的新来源。植物病害造成全球农作物产量损失的15%，对粮食安全构成威胁。杀真菌剂是一种关键的保护形式，代表了环境问题。另一种关键的保护形式是抗性基因育种，但这受到育种过程漫长、从性相容物种中选择基因有限以及田间有效时间短等因素的限制。本项目在前人研究的基础上，对Toll/白细胞介素-1受体域介导的烟酰胺腺嘌呤二核苷酸（NAD+）切割的分子基础和植物NLR复合物的结构进行了研究。这些知识将支持保护作物免受病原体侵害的长期目标。