Molecular mechanism of action of plant immune receptors

植物免疫受体作用的分子机制

• 批准号: DP160102244
• 负责人: Prof Bostjan Kobe
• 金额: $ 24.54万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102244
• 关键词: Molecular; mechanism; action; plant; immune

The project aims to improve our understanding of how plant resistance proteins function and to find new sources of these proteins. Effector-triggered immunity is a key mechanism by which plants detect invading pathogens and trigger immune responses. In this process, a pathogen effector (avirulence) protein is recognised by a plant resistance (NLR) protein. Building on genetic, biochemical and structural work on the flax, Arabidopsis and wheat immune receptors, the project focuses on understanding the molecular basis of action of NLR proteins using structural biology approaches complemented by mutagenesis and functional assays, in model as well as crop pathosystems. The new knowledge may support the manipulation of immune responses to reduce the economic and environmental implications of plant diseases.

该项目旨在提高我们对植物抗性蛋白功能的理解，并寻找这些蛋白的新来源。效应器触发的免疫是植物检测入侵病原体和触发免疫反应的关键机制。在这个过程中，病原体效应(无毒)蛋白被植物抗性(NLR)蛋白识别。该项目建立在亚麻、拟南芥和小麦免疫受体的遗传、生化和结构工作的基础上，重点是利用结构生物学方法，辅以突变和功能分析，在模型和作物病理系统中了解NLR蛋白的作用的分子基础。这一新知识可能会支持操纵免疫反应，以减少植物疾病对经济和环境的影响。