Structural biology and therapeutic targeting of proteins involved in infection and immunity

感染和免疫相关蛋白质的结构生物学和治疗靶向

• 批准号: nhmrc : 1110971
• 负责人: Prof Bostjan Kobe
• 金额: $ 51.94万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-biology-therapeutic-infection-immunity/663157
• 关键词: Structural; biology; therapeutic; targeting; proteins

Structural biology plays an essential role in uncovering how proteins function at the molecular level, and further facilitates strategies to develop therapeutics targeting the diseases these proteins are involved in. In the proposed work, I will focus on bacterial virulence factors, to develop new antibiotics and vaccination strategies, and proteins involved in innate immunity pathways, to develop therapeutics against a number of associated disorders including chronic inflammatory diseases.

结构生物学在揭示蛋白质如何在分子水平上发挥作用方面起着至关重要的作用，并进一步促进了针对这些蛋白质所涉及的疾病开发治疗方法的策略。在拟议的工作中，我将专注于细菌毒力因子，开发新的抗生素和疫苗接种策略，以及参与先天免疫途径的蛋白质，开发针对包括慢性炎症性疾病在内的许多相关疾病的治疗方法。