EPIDEMIOLOGY OF BREAST CANCER ON LONG ISLAND

描述：存在关于以下各项之间关联的冲突数据 有发病风险的血清OCCS(如DDE)和多氯联苯水平 乳腺癌。该应用程序旨在完成一个 以前支持的病例对照研究，以确定 这些物质在乳房的血清和脂肪组织中升高。 长岛确诊的癌症病例与来自长岛的对照组进行了比较 位置(良性乳腺疾病和手术对照)。到目前为止，338例 患者，418名女性良性乳腺疾病和197名手术对照 接受了819份脂肪样本和896份血清样本的采访 收好了。已经对其中四分之一的样本进行了分析， 初步结果表明，DDE和可能的某些多氯联苯同系物是 与乳腺癌风险增加有关。未来的计划是 继续进行以：1)完成对剩余3/4的 2)测定调脂后的OCCS血药浓度和 它们在血清和脂肪组织之间的分配；3)与OCC水平相关 与年龄、体重和位置相关，以调整乳腺癌的风险 这些混杂因素；4)确定调整后的风险估计是否与 肿瘤的雌激素受体状态；5)OCC水平与 通过随访病例了解乳腺癌的复发和死亡率；6)研究 短期(1-3年)血清OCC和PCB值的稳定性及其对血清PCB值的影响 在这些水平上进行治疗；7)估计乳腺癌风险，利用 对多氯联苯同系物的不同分类；以及8)确定 乳腺癌的OCC相关风险可与异型性程度相关 良性乳腺活检对照，使用样本的病理检查 从400多名患者中选出。

DESCRIPTION: There are conflicting data regarding the associations between serum levels of OCCs (e.g., DDE) and of PCB with the risk of developing breast cancer. The application is intended to complete a previously-supported, case-control study to determine whether the levels of these substances is elevated in the serum and adipose tissue of breast cancer cases, diagnosed on Long Island, compared to controls from the same location (benign breast disease and surgical controls). To date, 338 case patients, 418 women with benign breast disease and 197 surgical controls have been interviewed, and 819 adipose samples and 896 serum aliquots collected. One fourth of these samples have been analyzed and the preliminary results show that DDE and possibly certain PCB congeners are associated with increased risk of breast cancer. The future plan is to continue in order to: 1) complete assays on the remaining 3/4 of the samples; 2) determine the lipid-adjusted serum concentrations of OCCs and their partition between serum and adipose tissue; 3) correlate OCC levels with age, body mass, and location in order to adjust breast cancer risk for these confounders; 4) determine whether adjusted risk estimates differ by estrogen receptor status of the tumors; 5) correlate OCC levels with recurrence and mortality from breast cancer via follow-up cases; 6) study short term (1-3 yr.) stability of serum OCC and PCB levels and the impact of treatment on these levels; 7) estimate breast cancer risk, utilizing different classifications for PCB congeners; and 8) determine whether OCC-related risk of breast cancer can be correlated with degrees of atypia of the benign breast biopsy controls, using pathologic reviews of samples from over 400 patients.