SOLID STATE OPTICS FOR NONINVASIVE GLUCOSE MONITORS

该提案描述了一项开发新型固态硬盘的研究计划 半导体光接收器，用于工作在以下的组合区域中 近红外光谱。这些接收器是必要的，以提高 用于非侵入性血糖测量的光谱质量。数据 以表明葡萄糖可以在络合物中选择性地测量。 生物基质(未稀释的人血清和哺乳动物细胞培养 介质)用于在组合光谱上收集的近红外光谱 区域(2.08到2.38)。在此收集的非侵入性人体光谱 波长范围缺乏足够的信噪比，无法实现准确的 测量血糖。对仪器的分析表明， 探测器的性能目前限制了我们的进步领域。因此，我们 建议专门开发低噪声、高响应度探测器 专为此应用和此光谱范围而设计。具体地说 InGaAsSb合金将用于制造半导体探测器 波长在2.08到2.38微米之间。这种半导体材料 为这一光谱范围提供了理想的带隙，这将使 责任感。此外，这种合金可以与晶格匹配 商业上可用的GaSb基板，将最大限度地减少暗电流。 将这些新型光电探测器直接与定制设计相结合 跨阻抗放大电路将降低噪声。由此产生的 光电接收器将为光谱提供极佳的信噪比 收集在2.08到2.38微米之间。这份提案详细说明了 第一代接收器的制造和特性。 后续的世代将建立在光子学的基础上， 电子和光谱性能。

This proposal describes a research plan to develop novel solid-state semiconductor photoreceivers for operation in the combination region of the near infrared spectrum. These receivers are necessary to improve spectral quality for noninvasive measurements of blood glucose. Data is provided to show that glucose can be measured selectively in complex biological matrices (undiluted human serum and mammalian cell culture media) for near infrared spectra collected over the combination spectral region (2.08 to 2.38). Noninvasive human spectra collected over this wavelength range lack sufficient signal-to-noise to permit accurate blood glucose measurements. Analysis of the instrumentation reveals that detector performance currently limits our progress area. Hence, we propose to develop low-noise, high responsivity detectors specifically designed for this application and this spectral range. Specifically the alloy InGaAsSb will be used to fabricate semiconductor detectors for wavelengths between 2.08 and 2.38 microns. This semiconductor material provides an ideal bandgap for this spectral range which will maximize responsivity. Furthermore, this alloy can be lattice matched to commercially available GaSb substrates that will minimize dark currents. Coupling these novel photodetectors directly with custom-designed transimpedance amplifier circuits will reduce noise. The resulting photoreceivers will provide excellent signal-to-noise ratios for spectra collected between 2.08 to 2.38 microns. This proposal details the fabrication and characterization of a first generation of receivers. Subsequent generations will be constructed on the basis of photonic, electronic and spectroscopic performance.