Continuous near infrared glucose sensor

描述(由申请人提供)：描述了一项研究计划，旨在开发一种新型小型化固态光谱仪，设计用于近红外光谱(2.0-2.5米或4000-5000厘米-1)组合区域的分析测量。目标是开发一种坚固耐用的光谱仪微型传感器，能够在实验室外不理想和不受控制的环境条件下进行准确的分析测量。到目前为止的进展证明了这种方法的可行性和实用性，用于连续测量通过植入实验大鼠皮下的超滤探头收集的间质性液体中的葡萄糖。对目前的光谱仪进行了改进，以实现从一分钟内收集的光谱中检测葡萄糖的极限为1 mm。该研究计划旨在通过提高定制半导体发光二极管(LED)的输出、提高创新的焦平面阵列探测器系统的探测率、实施伴随参考通道以及开发数据分析方法来提高校准模型的长期稳定性来实现这些改进。提出了一种新的电子接口，以实现数据采集的定制化和小型化。光谱仪原型将在一系列体外和体内实验中进行表征和验证，其中包括对非麻醉、自由移动的实验室大鼠进行连续和选择性的血糖测量。在所要求的四年资助期结束时，我们的目标是拥有一种优化的近红外微型传感器光谱仪，准备在人体试验中进行评估，以连续测量血糖。公众健康相关性一种新型的葡萄糖传感器是基于一种创新的小型化、全固态近红外光谱仪，该光谱仪由一组定制的光电设备组成。总体目标是在非实验室条件下在一分钟内测量临床相关的血糖水平。分析特性将在实验室动物身上得到验证。

DESCRIPTION (provided by applicant): A research program is described to develop a novel miniaturized solid-state spectrometer designed for analytical measurements over the combination region of the near infrared spectrum (2.0-2.5 ?m or 4000-5000 cm-1). The objective is to develop a robust spectrometer microsensor that is capable of accurate analytical measurements under non-ideal and uncontrolled ambient conditions outside the laboratory. Progress to date demonstrates the feasibility and utility of this approach for the continuous measurement of glucose in interstitial fluid collected by an ultrafiltration probe implanted subcutaneously in laboratory rats. Improvements in the current spectrometer are identified to achieve a limit of detection of 1 mM for glucose from spectra collected over a one-minute period. The research plan is designed to realize these improvements by enhancing the output of custom-made semiconductor light emitting diodes (LEDs), improving the detectivity of an innovative focal plan array detector system, implementing a companion reference channel, and developing data analysis methods to improve the long-term stability of the calibration model. A new electronic interface is proposed to customize and miniaturize data acquisition. Spectrometer prototypes will be characterized and validated in a series of in vitro and in vivo experiments that include continuous and selective glucose measurements in non-anesthetized, freely moving laboratory rats. At the end of the requested four-year grant period, our objective is to have an optimized near infrared microsensor spectrometer that is ready for evaluation in human trials for the continuous measurement of glucose. PUBLIC HEALTH RELEVANCE A novel glucose sensor is proposed based on an innovative miniaturized, all solid-state near infrared spectrometer that is constructed from a set of customized optoelectronic devices. The overall objective is to measure clinically relevant levels of glucose in one minute under non- laboratory conditions. Analytical properties will be validated in laboratory animals.