Instrumental Designs for Near Infrared Glucose Monitors

近红外血糖监测仪的仪器设计

• 批准号: 6892067
• 负责人: MARK A. ARNOLD
• 金额: $ 16.94万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-15 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6892067
• 关键词: biomedical equipment development; blood filtration; blood glucose; blood tests; computer system hardware; glucose clamp technique; hypoglycemia; infrared spectrometry; laboratory rat; monitoring device; noninvasive diagnosis

DESCRIPTION (provided by applicant): Two novel solid-state instrumental designs are described for use in the noninvasive measurement of blood glucose. Both instruments implement transmission measurements of near-infrared light through a tissue sample and allow the encoding of multivariate calibration models in hardware. Each instrument is based on the sequential measurement of pre-defined combinations of near- infrared wavelengths that are specified in the form of filter bandpass functions. In the two designs, these filter profiles are generated with either a digital micromirror array (MMA) or an acousto-optic tunable filter (AOT F). The MMA allows the specification of filter profiles of arbitrary complexity, while the AOTF allows the generation of filters with simpler square-wave shapes. A computational model and numerical optimization procedures are described for use in defining optimal filter profiles that result in the measurement of unique spectral patterns that are selective for blood glucose. These filter profiles are analogous to the components extracted by multivariate calibration models from contiguous spectral data acquired by a conventional spectrometer. Performing these discrete filter-based measurements gains both throughput and multiplex advantages, and allows the creation of rugged instrumental designs that are compatible with noninvasive blood glucose measurements made by diabetic patients outside the controlled environment of the laboratory. Both in vitro experiments and in vivo studies with a rat model are proposed for use in characterizing the performance and analytical utility of these instrumental designs. The experimental and computational work will be directed to the overall goal of developing a noninvasive nocturnal hypoglycemic alarm.

描述（由申请人提供）：描述了两种用于无创血糖测量的新型固态仪器设计。这两种仪器都实现了近红外光通过组织样本的透射测量，并允许在硬件中对多变量校准模型进行编码。每种仪器都是基于以滤波器带通函数的形式指定的近红外波长的预定义组合的顺序测量。在这两种设计中，这些滤波器配置文件是由数字阵列（MMA）或声光可调谐滤波器（AOTF）生成的。MMA允许指定任意复杂的滤波器配置文件，而AOTF允许生成具有更简单的方波形状的滤波器。描述了一种计算模型和数值优化过程，用于定义最佳滤波器轮廓，该最佳滤波器轮廓导致对血糖具有选择性的独特光谱图案的测量。这些过滤器配置文件是类似的组件提取的多元校准模型从连续的光谱数据采集的常规光谱仪。执行这些基于离散滤波器的测量获得了吞吐量和多路复用的优势，并且允许创建坚固的仪器设计，其与糖尿病患者在实验室受控环境之外进行的无创血糖测量兼容。在体外实验和体内研究与大鼠模型提出用于表征这些仪器设计的性能和分析效用。实验和计算工作的总体目标是开发一种无创夜间低血糖报警器。