Instrumental Designs for Near Infrared Glucose Monitors

描述（由申请人提供）：描述了两种用于无创血糖测量的新型固态仪器设计。这两种仪器都实现了近红外光通过组织样本的透射测量，并允许在硬件中编码多变量校准模型。每个仪器都是基于预先定义的近红外波长组合的顺序测量，这些组合以滤波器带通函数的形式指定。在这两种设计中，这些滤波器轮廓是由数字微镜阵列（MMA）或声光可调滤波器（AOT F）生成的。MMA允许指定任意复杂度的滤波器配置文件，而AOTF允许生成具有更简单方波形状的滤波器。本文描述了一种计算模型和数值优化程序，用于定义可导致对血糖有选择性的独特光谱模式测量的最佳滤波器配置文件。这些滤波剖面类似于用多元校正模型从传统光谱仪获得的连续光谱数据中提取成分。执行这些基于离散滤波器的测量获得了吞吐量和多路复用的优势，并允许创建坚固的仪器设计，与实验室控制环境之外的糖尿病患者进行的无创血糖测量兼容。在体外实验和体内研究与大鼠模型被建议用于表征这些仪器设计的性能和分析效用。实验和计算工作将指导开发一个无创夜间低血糖警报的总体目标。

DESCRIPTION (provided by applicant): Two novel solid-state instrumental designs are described for use in the noninvasive measurement of blood glucose. Both instruments implement transmission measurements of near-infrared light through a tissue sample and allow the encoding of multivariate calibration models in hardware. Each instrument is based on the sequential measurement of pre-defined combinations of near- infrared wavelengths that are specified in the form of filter bandpass functions. In the two designs, these filter profiles are generated with either a digital micromirror array (MMA) or an acousto-optic tunable filter (AOT F). The MMA allows the specification of filter profiles of arbitrary complexity, while the AOTF allows the generation of filters with simpler square-wave shapes. A computational model and numerical optimization procedures are described for use in defining optimal filter profiles that result in the measurement of unique spectral patterns that are selective for blood glucose. These filter profiles are analogous to the components extracted by multivariate calibration models from contiguous spectral data acquired by a conventional spectrometer. Performing these discrete filter-based measurements gains both throughput and multiplex advantages, and allows the creation of rugged instrumental designs that are compatible with noninvasive blood glucose measurements made by diabetic patients outside the controlled environment of the laboratory. Both in vitro experiments and in vivo studies with a rat model are proposed for use in characterizing the performance and analytical utility of these instrumental designs. The experimental and computational work will be directed to the overall goal of developing a noninvasive nocturnal hypoglycemic alarm.