Continuous Near Infrared Glucose Sensor

描述（由申请人提供）：提出了一项研究计划，旨在开发和验证用于治疗和管理糖尿病的连续葡萄糖传感系统。中央传感元件是集成在定制的微流体腔室内的微型近红外光谱仪。超滤探针从皮下空间收集组织液样品，并将该样品运送到优化的光谱仪单元，在4600 - 4200 cm-1（2.17 - 2.38 um）的光谱范围内收集16 cm-1分辨率的近红外光谱。将使用多变量校准模型从所得光谱中提取葡萄糖浓度。这项研究计划的一个创新特点是光源和探测器的建设具有理想的特性，这一特定的光谱范围。这些光源和探测器将由分子束外延合成的新型半导体材料制成。将产生独特的半导体异质结构材料，以产生具有测量组织液样品中临床相关葡萄糖水平所需的光学特性的材料。坚固的光谱仪设计和强大的超滤采样系统相结合，将使连续运行几天成为可能。还提出了一种定制电子封装的开发，以便控制系统组件并将光谱信息广播到远程接收器。我们的目标是生产一个独立的连续血糖监测仪，它可以用作夜间报警或连续血糖监测仪。描述了体外和体内验证实验，以充分表征拟定的分析系统。11名研究人员的人才将结合起来，提供化学传感器，近红外光谱，化学计量学，微流体，微制造，生物医学超滤，半导体光学材料，分子束外延生长半导体材料合成，光学器件制造，电子，无线通信和动物模型和人类受试者的系统评估等关键领域的专业知识。

DESCRIPTION (provided by applicant): A research program is proposed to develop and validate a continuous glucose sensing system for the treatment and management of diabetes. The central sensing element is a miniature near infrared spectrometer that is integrated within a customized microfluidic chamber. An ultrafiltration probe collects a sample of interstitial fluid from the subcutaneous space and this sample is carried to an optimized spectrometer cell, where a 16 cm-1 resolution near infrared spectrum is collected over a spectral range of 4600 - 4200 cm-1 (2.17 - 2.38 um). A multivariate calibration model will be used to extract the glucose concentration from the resulting spectrum. An innovative feature of this research plan is the construction of both optical sources and detectors with ideal characteristics for this specific spectral range. These sources and detectors will be produced from novel semiconductor materials that will be synthesized by molecular beam epitaxy. Unique semiconductor heterostructure materials will be generated to produce materials with the optical properties necessary for measuring clinically relevant levels of glucose in samples of interstitial fluid. The combination of a sturdy spectrometer design and a robust ultrafiltration sampling system will make possible continuous operation over several days. Development of a custom electronics package is also proposed in order to control the system components and to broadcast the spectral information to a remote receiver. The goal is to produce a self-contained continuous glucose monitor, which can be used as either a nocturnal alarm or a continuous glucose monitor. Both in vitro and in vivo validation experiments are described to fully characterize the proposed analytical system. The talents of eleven researchers will be combined to provide expertise in the critical areas of chemical sensors, near infrared spectroscopy, chemometrics, microfluidics, microfabrication, biomedical ultrafiltration, semiconductor optical materials, semiconductor material synthesis by molecular beam epitaxial growth, optical device fabrication, electronics, wireless communications, and system evaluation in both animal models and human subjects.