NONINVASIVE CHEMICAL SENSOR FOR BLOOD GLUCOSE

这项研究计划的总体目标是开发光谱- 基于葡萄糖传感器，可用于治疗和控制 糖尿病 这种传感方法将基于近红外（NIR） 光谱学、最先进的光纤技术和先进的 计算机数据分析。 拟议工作的重点是 设计、建造和评估一种非侵入式传感器， 允许直接测量原位血糖水平， 采集血样 这项研究是建立在一系列 实验的设计，以证明决定性的近红外光谱， 再加上基于计算机的数据分析，可以用来确定 葡萄糖在1 - 20 mM浓度范围内定量地在生物学中 矩阵 本申请中描述的工作包括四个 主要组成部分：（1）扩大我们的初步可行性研究， 增加了样本矩阵的复杂性;（2）调查 仪器参数对拟定分析的影响;（3） 开发用于提取葡萄糖的优化数据分析算法 收集的近红外光谱信息;以及（4）开发 基于光纤技术的葡萄糖传感探头。 在整个 建议的工作，我们的研究工作的主要重点将是 开发精确和准确的葡萄糖传感方法， 到实际执行。

The overall goal of this research program is to develop spectroscopic- based glucose sensors that can be used in the treatment and control of diabetes. this sensing approach will be based on near-infrared (NIR) spectroscopy, state-of-the-art optical fiber technology, and advanced computer-based data analysis. The focus of the proposed work is the design, construction, and evaluation of a noninvasive sensor that will allow direct measurement of in situ blood glucose levels without collecting a blood sample. The proposed research is built upon a series of experiments designed to show conclusively that NIR spectroscopy, coupled with computer-based data analysis, can be used to determine glucose quantitatively in the 1 - 20 mM concentration range in biological matrices. The work described in this grant application consists of four major components: (1) extension of our initial feasibility studies to increase the complexity of the sample matrix; (2) investigation of the impact of instrumental parameters on the proposed analysis; (3) development of optimized data analysis algorithms for extracting glucose information from the collected NIR spectra; and (4) development of glucose sensing probes based on optical fiber technology. Throughout the proposed work, the principal focus of our research efforts will be to develop precise and accurate glucose sensing methods that are amenable to practical implementation.