GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
批准号:
3073657
负责人:
DAVID L KREULEN
金额:
$5.07万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1983
资助国家:
美国
项目状态:
已结题
起止时间:
1983-07-01 至 1988-06-30
中文摘要
这项研究的目的是描述神经通路的作用
英文摘要
The aim of this research is to delineate the role of nerve pathways
involving the abdominal prevertebral ganglia in controlling mesenteric
blood vessels and to determine the organization of the abdominal
nerve-vessel system. Experiments have been designed to determine: (1) the
organization of the sympathetic outflow to branches of the inferior
mesenteric and celiac arteries and the inferior mesenteric and portal
veins; (2) whether or not there are afferent pathways from the mesenteric
vasculature to neurons in the prevertebral ganglia; (3) whether there are
reflexes between different vascular regions in the mesentery and/or between
the mesenteric vasculature and the mesculature of the gastrointestinal
tract; (4) the nature of neuroeffector transmission from the postganglionic
fibers of the prevertebral ganglia to mesenteric vascular smooth muscle
cells. These studies will involve anatomical, physiological and
pharmcological approaches to these questions. In vitro preparations from
guinea pigs and cats that consist of the celiac plexus and inferior
mesenteric ganglion attached to selected abdominal organs will be used.
Preganglionic, postganglionic and afferent nerve fibers will be
electrically stimulated. Electrophysiological techniques will be used to
determine intracellular responses of neurons in the prevertebral ganglia
and vascular smooth muscle cells. Pressure recording techniques will be
used to distend and record the contractile responses of mesenteric vascular
and gastrointestinal segments. Pharmacologic techniques will be used to
determine the mechanisms which modulate neurotransmission in the ganglia
and to the blood vessels to determine how these mechanisms can be altered
with drug therapy. The goal of these studies will be to understand how the
autonomic nervous system controls the viscera and what role reflexes
between the viscera plays in this control. This knowledge will help us to
understand and design better treatment for diseases which involve the
autonomic nervous system; the nerves themselves as well as the organs they
innervate.
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NEURON SPECIFIC TARGETING OF ARTERIES AND VEINS IN HYPERTENSION
-
批准号:7452269
-
项目类别:
-
资助金额:$31.38万
-
财政年份:2007
-
负责人:DAVID L KREULEN
-
依托单位:
NEURON SPECIFIC TARGETING OF ARTERIES AND VEINS IN HYPERTENSION
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批准号:6999204
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项目类别:
-
资助金额:$28.09万
-
财政年份:2004
-
负责人:DAVID L KREULEN
-
依托单位:
Neuron-specific targeting of arteries and veins in hypertension
-
批准号:8148068
-
项目类别:
-
资助金额:$32.04万
-
财政年份:2003
-
负责人:DAVID L KREULEN
-
依托单位:
Neuron-specific targeting of arteries and veins in hypertension
-
批准号:8374505
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项目类别:
-
资助金额:$31.05万
-
财政年份:2003
-
负责人:DAVID L KREULEN
-
依托单位:
Neuron-specific targeting of arteries and veins in hypertension
-
批准号:8452154
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项目类别:
-
资助金额:$28.94万
-
财政年份:2003
-
负责人:DAVID L KREULEN
-
依托单位:
SPECIFICITY OF THE INNERVATION OF ARTERIES AND VEINS
-
批准号:2904447
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项目类别:
-
资助金额:$22.18万
-
财政年份:1997
-
负责人:DAVID L KREULEN
-
依托单位:
SPECIFICITY OF THE INNERVATION OF ARTERIES AND VEINS
-
批准号:2441963
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项目类别:
-
资助金额:$21.47万
-
财政年份:1997
-
负责人:DAVID L KREULEN
-
依托单位:
SPECIFICITY OF THE INNERVATION OF ARTERIES AND VEINS
-
批准号:2839084
-
项目类别:
-
资助金额:$21.67万
-
财政年份:1997
-
负责人:DAVID L KREULEN
-
依托单位:
SPECIFICITY OF THE INNERVATION OF ARTERIES AND VEINS
-
批准号:6330135
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项目类别:
-
资助金额:$22.7万
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财政年份:1997
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负责人:DAVID L KREULEN
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依托单位:
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
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批准号:2216179
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项目类别:
-
资助金额:$12.44万
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财政年份:1994
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负责人:DAVID L KREULEN
-
依托单位:
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
-
批准号:2216180
-
项目类别:
-
资助金额:$12.21万
-
财政年份:1992
-
负责人:DAVID L KREULEN
-
依托单位:
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
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批准号:3073659
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项目类别:
-
资助金额:$5.02万
-
财政年份:1983
-
负责人:DAVID L KREULEN
-
依托单位:
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
-
批准号:3073658
-
项目类别:
-
资助金额:$5.05万
-
财政年份:1983
-
负责人:DAVID L KREULEN
-
依托单位:
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
-
批准号:3339316
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项目类别:
-
资助金额:$10.05万
-
财政年份:1981
-
负责人:DAVID L KREULEN
-
依托单位:
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
-
批准号:3339317
-
项目类别:
-
资助金额:$9.87万
-
财政年份:1981
-
负责人:DAVID L KREULEN
-
依托单位:
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
-
批准号:3339313
-
项目类别:
-
资助金额:$7.63万
-
财政年份:1981
-
负责人:DAVID L KREULEN
-
依托单位:
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
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批准号:3339310
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项目类别:
-
资助金额:$9.99万
-
财政年份:1981
-
负责人:DAVID L KREULEN
-
依托单位:
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
-
批准号:3339315
-
项目类别:
-
资助金额:$9.87万
-
财政年份:1981
-
负责人:DAVID L KREULEN
-
依托单位:
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
-
批准号:3339319
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项目类别:
-
资助金额:$11.96万
-
财政年份:1981
-
负责人:DAVID L KREULEN
-
依托单位:
GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS
-
批准号:3339318
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项目类别:
-
资助金额:$10.28万
-
财政年份:1981
-
负责人:DAVID L KREULEN
-
依托单位: