GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS

这项研究的目的是描绘神经通路的作用。 主治累及腹椎前神经节 并确定肠系膜血管的组织 腹部神经-血管系统。实验的目的是为了 确定：(1)血管传入通路的特征 肠系膜动脉、静脉至交感神经节； 交感神经肌肉传递的特点 神经至肠系膜动静脉；(3)特点 通向椎前的肠道非胆碱能感觉通路 神经节：4)不同血管之间是否有反射 肠系膜和/或肠系膜血管系统之间的区域 和胃肠道的肌肉组织(5) 神经节内反射通路的药理学特性 在神经印迹血管交界处。这些研究将涉及 对这些的解剖、生理学和药理学研究 问题。豚鼠、兔、大鼠体外制剂 和猫，由腹膜神经丛和肠系膜下层组成 将使用附在选定腹部器官上的神经节。 节前、节后和传入神经纤维 是电刺激的。电生理技术将是 用于确定脑内神经元的细胞内反应 椎前神经节和血管平滑肌细胞。压力 记录技术将被用来扩展和记录 肠系膜血管和胃肠道的收缩反应 细分市场。将使用药理学技术来确定 调节神经节内神经传递的机制 血管来确定这些机制是如何改变的 用药物治疗。这些研究的目标将是了解 自主神经系统如何控制血管以及控制什么 内脏之间的反射在这种控制中起着作用。这 知识将帮助我们理解和设计更好的治疗方法 用于涉及自主神经系统的疾病；神经 自我以及它们所支配的器官。

The aim of this research is to delineate the role of nerve pathways involving the abdominal prevertebral ganglia in controlling mesenteric blood vessels and to determine the organization of the abdominal nerve-vessel system. Experiments have been designed to determine: (1) characteristics of vascular afferent pathways from mesenteric arteries veins to the sympathetic ganglia; (2) the characteristics of neuromuscular transmissions from sympathetics nerves to mesenteric arteries and veins; (3) the characteristics of intestinal noncholinergic sensory pathways to the prevertebral ganglia: 4) whether there are reflexes between different vascular regions in the mesentery and/or between the mesenteric vasculature and the musculature of the gastrointestinal tract (5) the pharmacologic properties of the reflex pathways within the ganglia and at the nerve-blot vessel junction. These studies will involve anatomical physiological and pharmacologic approaches to these questions. In vitro preparations from guinea pigs, rabbits, rats and cats that consist of the celiac plexus and inferior mesenteric ganglion attached to selected abdominal organs will be used. Preganglionic, postganglionic and afferent nerve fibers will be electrically stimulated. Electrophysiological techniques will be used to determine intracellular responses of neurons in the prevertebral ganglia and vascular smooth muscle cells. Pressure recording techniques will be used to distend and record the contractile responses of mesenteric vascular and gastrointestinal segment. Pharmacologic techniques will be used to determine the mechanisms which modulate neurotransmission in the ganglia and to the blood vessels to determine how these mechanism can be altered with drug therapy. The goal of these studies will be to understand how to autonomic nervous system controls blood vessels and what role reflexes between the viscera plays in this control. This knowledge will help us to understand and design better treatment for diseases which involve the autonomic nervous system; the nerves the selves well as the organs they innervate.