GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS

这项研究的目的是描绘神经通路的作用， 涉及腹部椎前神经节控制 肠系膜血管，并确定组织的 腹部神经血管系统 实验的目的是 确定：（1）血管传入通路的特征， 交感神经节的肠系膜动静脉;（2） 交感神经的神经肌肉传递特征 肠系膜动、静脉的神经分布特点 肠非胆碱能感觉通路到椎前 神经节：4）不同血管间是否有反射 肠系膜中和/或肠系膜脉管系统之间的区域 和胃肠道的肌肉组织（5）， 神经节内反射通路的药理学特性 以及神经-印迹血管连接处。 这些研究将涉及 解剖生理学和药理学的方法， 问题. 豚鼠、家兔、大鼠的体外制剂 猫的腹腔神经丛和肠系膜下动脉 将使用连接到选定腹部器官的神经节。 节前、节后和传入神经纤维将 电刺激。 电生理技术将是 用于确定神经元的细胞内反应， 椎前神经节和血管平滑肌细胞。 压力 记录技术将用于扩张和记录 肠系膜血管和胃肠收缩反应 片段 将使用药理学技术来确定 调节神经节中神经传递的机制， 来确定这些机制如何被改变 药物治疗 这些研究的目的是了解 如何自主神经系统控制血管和什么 内脏之间的反射在这种控制中起作用。 这 知识将帮助我们理解和设计更好的治疗方法， 用于涉及自主神经系统的疾病;神经 以及它们所支配的器官。

The aim of this research is to delineate the role of nerve pathways involving the abdominal prevertebral ganglia in controlling mesenteric blood vessels and to determine the organization of the abdominal nerve-vessel system. Experiments have been designed to determine: (1) characteristics of vascular afferent pathways from mesenteric arteries veins to the sympathetic ganglia; (2) the characteristics of neuromuscular transmissions from sympathetics nerves to mesenteric arteries and veins; (3) the characteristics of intestinal noncholinergic sensory pathways to the prevertebral ganglia: 4) whether there are reflexes between different vascular regions in the mesentery and/or between the mesenteric vasculature and the musculature of the gastrointestinal tract (5) the pharmacologic properties of the reflex pathways within the ganglia and at the nerve-blot vessel junction. These studies will involve anatomical physiological and pharmacologic approaches to these questions. In vitro preparations from guinea pigs, rabbits, rats and cats that consist of the celiac plexus and inferior mesenteric ganglion attached to selected abdominal organs will be used. Preganglionic, postganglionic and afferent nerve fibers will be electrically stimulated. Electrophysiological techniques will be used to determine intracellular responses of neurons in the prevertebral ganglia and vascular smooth muscle cells. Pressure recording techniques will be used to distend and record the contractile responses of mesenteric vascular and gastrointestinal segment. Pharmacologic techniques will be used to determine the mechanisms which modulate neurotransmission in the ganglia and to the blood vessels to determine how these mechanism can be altered with drug therapy. The goal of these studies will be to understand how to autonomic nervous system controls blood vessels and what role reflexes between the viscera plays in this control. This knowledge will help us to understand and design better treatment for diseases which involve the autonomic nervous system; the nerves the selves well as the organs they innervate.