GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS

这项研究的目的是描绘神经通路的作用， 涉及控制肠系膜的腹椎前神经节 血管并确定腹部的组织 神经血管系统 设计实验以确定：（1） 下交感神经分支的组织 肠系膜动脉和腹腔动脉以及肠系膜下动脉和门静脉 静脉;（2）是否有来自肠系膜的传入途径 椎前神经节中神经元的血管;（3）是否有 肠系膜中不同血管区域之间和/或 肠系膜血管系统和胃肠系膜 （4）神经效应物从节后传递的性质 椎前神经节至肠系膜血管平滑肌的纤维 细胞 这些研究将涉及解剖学、生理学和 药物学方法来解决这些问题。 体外制剂， 豚鼠和猫，包括腹腔神经丛和下 将使用附着于选定腹部器官的肠系膜神经节。 节前、节后和传入神经纤维将 电刺激。 电生理技术将用于 确定椎前神经节中神经元的细胞内反应 和血管平滑肌细胞。 压力记录技术将是 用于扩张并记录肠系膜血管的收缩反应 和胃肠道。 药理学技术将用于 确定调节神经节中神经传递的机制 和血管来确定这些机制如何被改变 药物治疗 这些研究的目标是了解 自主神经系统控制内脏和什么作用反射 在控制中起着重要作用。 这些知识将帮助我们 了解和设计更好的治疗方法， 自主神经系统;神经本身以及器官， 使神经活动。

The aim of this research is to delineate the role of nerve pathways involving the abdominal prevertebral ganglia in controlling mesenteric blood vessels and to determine the organization of the abdominal nerve-vessel system. Experiments have been designed to determine: (1) the organization of the sympathetic outflow to branches of the inferior mesenteric and celiac arteries and the inferior mesenteric and portal veins; (2) whether or not there are afferent pathways from the mesenteric vasculature to neurons in the prevertebral ganglia; (3) whether there are reflexes between different vascular regions in the mesentery and/or between the mesenteric vasculature and the mesculature of the gastrointestinal tract; (4) the nature of neuroeffector transmission from the postganglionic fibers of the prevertebral ganglia to mesenteric vascular smooth muscle cells. These studies will involve anatomical, physiological and pharmcological approaches to these questions. In vitro preparations from guinea pigs and cats that consist of the celiac plexus and inferior mesenteric ganglion attached to selected abdominal organs will be used. Preganglionic, postganglionic and afferent nerve fibers will be electrically stimulated. Electrophysiological techniques will be used to determine intracellular responses of neurons in the prevertebral ganglia and vascular smooth muscle cells. Pressure recording techniques will be used to distend and record the contractile responses of mesenteric vascular and gastrointestinal segments. Pharmacologic techniques will be used to determine the mechanisms which modulate neurotransmission in the ganglia and to the blood vessels to determine how these mechanisms can be altered with drug therapy. The goal of these studies will be to understand how the autonomic nervous system controls the viscera and what role reflexes between the viscera plays in this control. This knowledge will help us to understand and design better treatment for diseases which involve the autonomic nervous system; the nerves themselves as well as the organs they innervate.