ACADEMIC NURSING HOME

约翰霍普金斯学术护理之家（JHANH）既代表了一个特定的 项目针对的现象和有关的问题， 过度肥胖和人类衰老之间的相互作用， 鼓励、审查、协调和促进机制 对人类衰老相关问题的进一步研究。 虽然以 巴尔的摩市医院（BCH）校园内的机构（梅森F。 巴尔的摩勋爵慢性病医院和熟练护理设施 市医院和国家老年学研究中心 老龄化研究所），JHANH将利用广泛的人类和 约翰霍普金斯医疗机构的非人力资源， 特别是医学院、卫生与公共卫生学院， 和（1984年重新启动）护理学院。 核心设施 将提供行政、科学咨询和审查职能， 具有生物统计咨询专业知识的患者登记处， 将所有研究受试者纳入衰老-肥胖项目的机制， 患者在实践中的关键BCH初级保健医生，患者在 MFL和老年居民流行病学调查中招募的受试者 东南部巴尔的摩社区的人 核心小组推动的试点研究 包括那些旨在详细说明生命的自然历史， MFL和新入院患者的康复。 的 四个具体项目代表了一个紧密结合的方法， 代谢调节的复杂现象，心肺生理学 （强调运动和热量调节），睡眠生理学，以及 神经心理功能 在这个多方面的项目禁烟 三个年龄组（45-49、60-74和75岁及以上）的肥胖男性受试者 将在这四个领域接受基线评估， 他们将被随机分配到观察-控制，减肥， 低热量治疗或耐力有氧运动训练。 经过十二 这些评估将重复进行，受试者将被重新分配到 观察状态，并在36个月后再次进行评估 首次进入研究。 因此，这项研究将解决问题 与数量有关（通过肥胖对 心血管风险概况）和质量（通过睡眠和相关 老年人生活中的神经心理障碍 肥胖症盛行的地区

The Johns Hopkins Academic Nursing Home (JHANH) represents both a specific program project directed toward phenomena and problems related to the interaction between excess adiposity and aging in the human and also a mechanism for encouraging, reviewing, coordinating, and facilitating additional research on problems relevant to human aging. While centered in the institutions on the Baltimore City Hospitals (BCH) campus (the Mason F. Lord [MFL] chronic hospital and skilled nursing facility, the Baltimore City Hospital, and the Gerontology Research Center of the National Institute on Aging), the JHANH will capitalize upon the extensive human and non-human resources of the Johns Hopkins Medical Institutions at large, notably the School of Medicine, the School and Hygiene and Public Health, and (when re-activated in 1984) the School of Nursing. The core facility will provide administration, scientific advisory and review functions, and a patient registry with biostatistical consultative expertise and the mechanism to enroll all study subjects in the aging-adiposity projects, patients in the practices of key BCH primary care physicians, patients in MFL, and subjects enrolled in an epidemiologic survey of elderly residents of the Southeast Baltimore community. Pilot studies promoted by the core include those directed toward detailing the natural history of life in the MFL and rehabilitation of patients newly admitted to that facility. The four specific projects represent a tightly-integrated approach to the complex phenomena of metabolic regulation, cardiopulmonary physiology (emphasizing exercise and heat regulation), sleep physiology, and neuropsychological function. In this multi-faceted project non-smoking obese male subjects of three age groups (45-49, 60-74, and 75 and older) will receive baseline evaluations in these four spheres, following which they will be randomly assigned to observation-control, weight loss through hypocaloric therapy, or endurance aerobic exercise training. After twelve months these assessments will be repeated, the subject re-assigned to observational status, and assessment repeated once again 36 months after initial entry into the study. Thus this research will address problems related both to the quantity (via the central effects of obesity upon cardiovascular risk profiles) and quality (via sleep and related neuropsychological disturbances) of life of aging man in Occidental society in which excess adiposity is so prevalent.