ENDOCRINE ASPECTS OF HUMAN NEOPLASIA

人类肿瘤的内分泌方面

• 批准号: 3095646
• 负责人: SHLOMO MELMED
• 金额: $ 69.49万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3095646
• 关键词: endocrine neoplasm; molecular oncology

This Program of Excellence in Endocrinology Research aims to integrate research efforts into the study of endocrine aspects of human neoplasia. The five component projects include: 1. Endocrinology of a parathyroid-hormone-related human tumor protein; 2. Vitamin D endocrine system in human lymphoma; 3. Tumor suppressor genes in human thyroid neoplasms; 4. Mechanisms of human pituitary tumorigenesis; 5. Human ovarian cancer and p53. Three core units will provide expert multidisciplinary support to these projects. They include Administration, Laboratory, and Cytogenetics Core Laboratories. This program brings a multidisciplinary approach to study fundamental mechanisms involved in neoplastic and paraneoplastic endocrine syndromes. The synergism of these research projects will provide basic cellular and molecular insights into the pathophysiology and management of patients with tumors of endocrine organs (thyroid pituitary and ovary), and of syndromes caused by abnormal elaboration of endocrine products by non-endocrine tumors (hypercalcemia and cachexia). This will lead to further understanding of the linkage between disordered endocrine function and the neoplastic process in patients harboring both endocrine and non-endocrine tumors.

该内分泌学研究卓越计划旨在 将研究工作纳入内分泌方面的研究， 人类肿瘤 这五个项目包括：1. 甲状旁腺激素相关的人类肿瘤蛋白的内分泌学; 2.维生素D内分泌系统在淋巴瘤中的作用; 3.肿瘤 人类甲状腺肿瘤中的抑制基因; 4.人的机制 垂体肿瘤发生; 5.人卵巢癌与p53 三 核心单位将向这些机构提供多学科专家支助。 项目 它们包括管理、实验室和 细胞遗传学核心实验室。 该计划带来了多学科的方法来研究 肿瘤和副肿瘤的基本机制 内分泌综合征 这些研究项目的协同作用将 提供基本的细胞和分子的见解， 内分泌肿瘤患者的病理生理学和管理 器官（甲状腺、垂体和卵巢），以及 非内分泌肿瘤对内分泌产物的异常加工 （高钙血症和恶病质）。 这将导致进一步 了解内分泌功能紊乱 和肿瘤的过程中，患者窝藏内分泌和 非内分泌肿瘤