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The neurobiology of human working memory for threat: A multi-method approach

人类威胁工作记忆的神经生物学：多方法研究

基本信息

批准号：
BB/G021538/2
负责人：
Jane Raymond
金额：
$ 8.39万
依托单位：
University of Birmingham
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2012
资助国家：
英国
起止时间：
2012 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FG021538%2F2
关键词：
neurobiology human working memory threat

项目摘要

This project will explore how our ability to remember and think about information immediately after perceiving it is affected by how emotional that information is. Previous research conducted by scientists a Bangor University showed that images associated with threat, e.g., angry faces, are more likely to be remembered over brief intervals than non-threatening images, e.g., faces with a neutral expression. This project will build on those previous studies by exploring how emotional information, including images and sounds that are fear evoking, gain preferential processing by the brain. The study will use brain-imaging techniques to investigate the brain systems that control how emotional information influences short term memory. It will also explore the possibility that specific bio-chemicals in the brain, called neurotransmitters, regulate cognitive responses to emotional information. To do this, the project will study short-term memory for emotional information in patients with Parkinson's disease because they are known to be deficient in a specific neurotransmitter that is highly likely to be important in emotional regulation of short-term memory. Asking the same question but using a different method, other parts of the project will examine how genetic variation in the neurotransmitter systems in healthy human adults can be used to account for variations in short term memory for emotional information. The results of the project will provide insight into how the brain uses motivationally relavent information to control memory and conscious experience.

这个项目将探索我们在感知信息后立即记住和思考信息的能力如何受到信息的情感影响。班戈尔大学的科学家们先前进行的研究表明，与威胁有关的图像，愤怒的面孔比非威胁性的图像更容易在短暂的时间间隔内被记住，例如，一张中性的脸。这个项目将建立在这些以前的研究，探索如何情绪信息，包括图像和声音，是唤起恐惧，获得大脑的优先处理。这项研究将使用大脑成像技术来研究控制情绪信息如何影响短期记忆的大脑系统。它还将探索大脑中被称为神经递质的特定生物化学物质调节对情绪信息的认知反应的可能性。为了做到这一点，该项目将研究帕金森病患者的情绪信息的短期记忆，因为已知他们缺乏一种特定的神经递质，这种神经递质很可能对短期记忆的情绪调节很重要。问同样的问题，但使用不同的方法，该项目的其他部分将研究如何在健康的成年人的神经递质系统的遗传变异可以用来解释短期记忆的情绪信息的变化。该项目的结果将提供深入了解大脑如何使用动机相关信息来控制记忆和意识体验。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A threatening face in the crowd: effects of emotional singletons on visual working memory.

人群中一张充满威胁的面孔：情绪单身对视觉工作记忆的影响。

DOI：
10.1037/a0033970
发表时间：
2014
期刊：
Journal of experimental psychology. Human perception and performance
影响因子：
0
作者：
Thomas PM
通讯作者：
Thomas PM

"Distracters" Do Not Always Distract: Visual Working Memory for Angry Faces is Enhanced by Incidental Emotional Words.

DOI：
10.3389/fpsyg.2012.00437
发表时间：
2012
期刊：
Frontiers in psychology
影响因子：
3.8
作者：
Jackson MC;Linden DE;Raymond JE
通讯作者：
Raymond JE

ZNF804A genotype modulates neural activity during working memory for faces.

DOI：
10.1159/000344001
发表时间：
2013
期刊：
Neuropsychobiology
影响因子：
3.2
作者：
Linden DE;Lancaster TM;Wolf C;Baird A;Jackson MC;Johnston SJ;Donev R;Thome J
通讯作者：
Thome J

Value conditioning modulates visual working memory processes.