ARTHRITIS AND MUSCULOSKELETAL DISEASES CENTER

这是对多功能关节炎中心的竞争性更新，该中心拥有 自1977年以来一直存在，它支持一个多学科小组 临床、社会和基础研究人员的各种基础和应用 风湿病和肌肉骨骼疾病方面的项目。MAC拥有 是发展该部的主要力量 风湿病/免疫学，自上一个资助期以来， 在临床监督和支持方面增加责任 调查人员。其核心单位被调查人员广泛使用在和 在学院之外。其中一个核心，形态核心，将是 由于首席调查员接受了一个新的职位，因此停止了工作。一个 提出了分子生物学的新核心。教育学、流行病学 和卫生服务研究部分，提出了四个项目。这个 首次研究了马萨诸塞州慢性莱姆病的流行病学； 第二，测试一种在关键变化中帮助决策的方法 风湿性关节炎患者的治疗方案；第三个方案检查一个 一组椎管狭窄患者评估治疗结果 保守治疗与手术的对比；第四个是对 缅因州腕管手术的流行病学研究是首要目标 用新的预后仪器评价保守治疗和手术治疗 腕管综合征的治疗。 提出了四项发展和可行性研究。其中一项研究是 耶尔森氏菌反应性关节炎的分子和临床流行病学。这个 第二项研究检查易感性和发病年龄的遗传预测因素。 患有系统性红斑狼疮的非裔美国人；第三个使用莱姆病的小鼠模型 以阐明疾病的致病机制；第四部分研究伽马 类风湿关节炎中的Delta T细胞。

This is a competitive renewal of a Multipurpose Arthritis Center that has been in existence since 1977 which supports a multidisciplinary group of clinical, social and basic researchers in a variety of basic and applied projects in rheumatic disease and musculoskeletal disorders. The MAC has been a major force in the development of the Department of Rheumatology/Immunology and, since the last funding period, has taken on added responsibilities in the supervision and support of clinical investigators. Its core units are used extensively by investigators in and outside the Institution. One core, the Morphology Core, will be discontinued as the principal investigator has accepted a new position. A new core in molecular biology is proposed. In the Education, Epidemiology and Health Services Research Component, four projects are proposed. The first examines epidemiology of chronic lyme disease in Massachusetts; the second tests an approach to assist decision making in the critical changes of treatment for patients with rheumatoid arthritis; the third examines a group of individuals with spinal stenosis to assess the outcomes of conservative management versus surgery; the fourth is an examination of the epidemiology of carpal tunnel surgery in Maine and is the first objective evaluation by newer outcome instruments of the conservative and surgical management of carpal tunnel syndrome. Four development and feasibility studies are proposed. One examines the molecular and clinical epidemiology of yersinia reactive arthritis. The second examines genetic predictors of susceptibility and the age of onset of African Americans with SLE; the third uses a mouse model of lyme disease to elucidate mechanisms of disease causation; and the fourth examines gamma delta T cells in rheumatoid arthritis.