NIAMS MULTIDISCIPLINARY CLINICAL RESEARCH CENTER

NIAMS 多学科临床研究中心

• 批准号: 6345815
• 负责人: MATTHEW H. LIANG
• 金额: $ 133.92万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6345815
• 关键词: arthritis; clinical research; human subject

This proposal is in response to RFA AR-00-0012, NIAMS Multi- disciplinary Clinical Research Center and is a watershed for the phasing out of the Multipurpose Arthritis Center program and a transition to a Clinical Research Center. Building on a rigorous active preclinical research program and investigator initiated clinical sciences program built over 20 years, we submit 3 proposals whose goals is to improve patient outcomes, a Biometry and Methodology Care to provide consultation and practical support to all projects and Administrative care to enhance interactions and responsiveness to new research opportunities. The research goals of project 1 are to understand the relationships between surgeon-and hospital-volume of total knee arthroplasty and to elucidate the mechanisms by which volume affects outcomes. To know these mechanisms will allow us to improve the effectiveness of this major procedure. It uses powerful statistical tools of claim analysis. Project 2 dissects the effects of functional literacy on outcome and tests a novel intervention to overcome the health disadvantages for subjects with systemic rheumatic diseases who have literacy problems. It breaks new ground in arthritis and musculoskeletal diseases and new methods have been developed to permit its study. It breaks new ground in arthritis and musculoskeletal diseases and new methods have been developed to permit its study. Project 3 attempts to improve SLE patients outcomes and reduce the incidence of accelerated atherosclerosis. That patients with SLE have an exceedingly high risk of accelerated atherosclerosis. That patients with SLE have an exceedingly high risk of accelerated atherosclerosis has been known for over 20 years. It's prevention is unknown the project is a proof of concept study using a cardiac risk profile as a surrogate endpoint.

本提案是对RFA AR-00-0012（NIAMS多学科临床研究中心）的回应，是逐步淘汰多功能关节炎中心项目并过渡到临床研究中心的分水岭。基于20多年来建立的严格的积极临床前研究计划和研究者发起的临床科学计划，我们提交了3项提案，其目标是改善患者结局，生物统计学和方法学护理，为所有项目提供咨询和实际支持，以及行政护理，以加强对新研究机会的互动和响应。项目1的研究目标是了解全膝关节置换术的外科医生和医院数量之间的关系，并阐明数量影响结果的机制。了解这些机制将使我们能够提高这一重要程序的有效性。它使用强大的索赔分析统计工具。项目2剖析了功能性识字对结果的影响，并测试了一种新的干预措施，以克服有识字问题的全身性风湿性疾病受试者的健康劣势。它在关节炎和肌肉骨骼疾病方面开辟了新的领域，并开发了新的方法来进行研究。它在关节炎和肌肉骨骼疾病方面开辟了新的领域，并开发了新的方法来进行研究。项目3试图改善SLE患者的预后并降低加速动脉粥样硬化的发生率。SLE患者有极高的风险加速动脉粥样硬化。SLE患者具有极高的加速动脉粥样硬化的风险，这一点已被发现超过20年。它的预防是未知的，该项目是一项使用心脏风险概况作为替代终点的概念验证研究。