CONTROLLED TRIAL OF PRIMARY AND SECONDARY PREVENTION PROGRAM FOR LYME DISEASE

1976年及以后对莱姆病的描述 其传播方式、致病生物体和 治疗是风湿病最重要的进展之一 过去的20年。从理论上讲，莱姆病可以预防和根除 但在实践中，它作为公共卫生问题继续增长。我们 提出了一项包含40,000名受试者的大型简单随机对照试验 评估创新的教育初级预防计划 针对高危人群，旅行者前往带有 北美报告的莱姆病发病率最高。渡船 到楠塔基特岛将随机进行实验干预 它是基于当代健康教育原则，还是为了 控制干预。年内将进行经济评估 审判的背景。

The description of Lyme disease in 1976 and subsequent characterization of its mode of transmission, causative organism and treatment is one of the most important advances in rheumatology in the last 20 years. In theory Lyme disease could be prevented eradicated but in practice it continues to grow as public health problem. We propose a large simple randomized controlled trail of 40,000 subjects to evaluate an innovative educational primary prevention program directed towards a high-risk population, travelers to an island with the highest reported rates of Lyme disease in North America. Ferry boats to Nantucket Island will be randomized to Experimental intervention which is based on contemporary health education principles or to a Control intervention. An economic evaluation will be conducted in the context of the trial.