NIAMS MULTIDISCIPLINARY CLINICAL RESEARCH CENTER

该提案是对RFA AR-00-0012， NIAMS多学科临床研究中心的回应，是逐步退出多用途关节炎中心项目并向临床研究中心过渡的分水岭。在严谨的临床前研究项目和研究者发起的临床科学项目的基础上，我们提交了三个提案，其目标是改善患者的治疗效果，一个生物测量和方法护理，为所有项目提供咨询和实际支持，以及行政护理，以加强互动和对新研究机会的响应。项目1的研究目标是了解外科手术量和医院全膝关节置换术量之间的关系，并阐明容量影响结果的机制。了解这些机制将使我们能够提高这一重大程序的有效性。它使用强大的索赔分析统计工具。项目2剖析了功能性读写能力对结果的影响，并测试了一种新的干预措施，以克服具有读写能力问题的系统性风湿病受试者的健康劣势。它在关节炎和肌肉骨骼疾病方面开辟了新的领域，并开发了新的方法来进行研究。它在关节炎和肌肉骨骼疾病方面开辟了新的领域，并开发了新的方法来进行研究。项目3试图改善SLE患者的预后，降低加速动脉粥样硬化的发生率。SLE患者加速动脉粥样硬化的风险极高。20多年来，人们已经知道SLE患者加速动脉粥样硬化的风险极高。该项目是一项概念验证研究，使用心脏风险概况作为替代终点。

This proposal is in response to RFA AR-00-0012, NIAMS Multi- disciplinary Clinical Research Center and is a watershed for the phasing out of the Multipurpose Arthritis Center program and a transition to a Clinical Research Center. Building on a rigorous active preclinical research program and investigator initiated clinical sciences program built over 20 years, we submit 3 proposals whose goals is to improve patient outcomes, a Biometry and Methodology Care to provide consultation and practical support to all projects and Administrative care to enhance interactions and responsiveness to new research opportunities. The research goals of project 1 are to understand the relationships between surgeon-and hospital-volume of total knee arthroplasty and to elucidate the mechanisms by which volume affects outcomes. To know these mechanisms will allow us to improve the effectiveness of this major procedure. It uses powerful statistical tools of claim analysis. Project 2 dissects the effects of functional literacy on outcome and tests a novel intervention to overcome the health disadvantages for subjects with systemic rheumatic diseases who have literacy problems. It breaks new ground in arthritis and musculoskeletal diseases and new methods have been developed to permit its study. It breaks new ground in arthritis and musculoskeletal diseases and new methods have been developed to permit its study. Project 3 attempts to improve SLE patients outcomes and reduce the incidence of accelerated atherosclerosis. That patients with SLE have an exceedingly high risk of accelerated atherosclerosis. That patients with SLE have an exceedingly high risk of accelerated atherosclerosis has been known for over 20 years. It's prevention is unknown the project is a proof of concept study using a cardiac risk profile as a surrogate endpoint.