CONTROLLED TRIAL OF PRIMARY AND SECONDARY PREVENTION PROGRAM FOR LYME DISEASE

莱姆病一级和二级预防规划对照试验

• 批准号: 6217117
• 负责人: MATTHEW H. LIANG
• 金额: $ 15.71万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6217117
• 关键词: Lyme disease; clinical research; communicable disease control; disease /disorder prevention /control; disease /disorder proneness /risk; education evaluation /planning; human subject; outcomes research

The description of Lyme disease in 1976 and subsequent characterization of its mode of transmission, causative organism and treatment is one of the most important advances in rheumatology in the last 20 years. In theory Lyme disease could be prevented eradicated but in practice it continues to grow as public health problem. We propose a large simple randomized controlled trail of 40,000 subjects to evaluate an innovative educational primary prevention program directed towards a high-risk population, travelers to an island with the highest reported rates of Lyme disease in North America. Ferry boats to Nantucket Island will be randomized to Experimental intervention which is based on contemporary health education principles or to a Control intervention. An economic evaluation will be conducted in the context of the trial.

1976年及其后对莱姆病的描述 其传播方式、病原体和 治疗是风湿病学最重要的进展之一， 过去20年 理论上莱姆病是可以预防和根除的 但在实践中，它作为公共卫生问题继续增长。 我们 提出一项包含40，000名受试者的大型简单随机对照试验 评估一项创新的教育性初级预防计划， 针对高风险人群，旅行者前往一个岛屿， 莱姆病在北美的发病率最高 渡船 南图克特岛将被随机分配到实验干预组 这是基于当代健康教育原则或一个 控制干预。经济评估将在 审判的背景。