Similar or different: neural signatures behind the cognitive effects of apolipoprotein E e4 polymorphism and cholinergic stimulation in healthy adults
相似或不同:载脂蛋白 E e4 多态性和胆碱能刺激对健康成年人的认知影响背后的神经特征
基本信息
- 批准号:BB/H000518/1
- 负责人:
- 金额:$ 50.11万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2010
- 资助国家:英国
- 起止时间:2010 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Recent work in our lab has identified a paradox - younger adults carrying a variant of a gene associated with memory impairment in older life appear to have better memories than their young adult peers who are not carrying this variant. This is surprising, because the variant is reliably associated with memory deficits in otherwise healthy people from about the fifth decade of life. In addition, we have demonstrated that as young adults, the carriers respond better than non-carriers to compounds that improve memory performance - so called 'cognitive enhancers'. The studies proposed in this grant will help us to understand how the brains of carriers and non-carriers of the gene variant differ, and how they change as people move from young to middle adulthood. We will image the brains of younger and mid-aged adults who carry the gene variant and compare them to the brains of age-matched non-carriers. In particular, we will compare the activity in areas of the brain that are used during important everyday memory tasks. The experiments will reveal whether having the variant gene improves the way those areas of the brain are used in typical and in challenging situations. We will establish why carriers of the variant get an extra cognitive boost from cognitive enhancers. We believe that the gene variant and cognitive enhancers are stimulating different brain areas, and that the added value of having the two together produces extra benefits to the carriers of the gene variant. Finally, we will determine whether the better response in young carriers to a cognitive enhancing drug continues undiminished in mid-age. Because the variant of the gene is linked to memory impairments in healthy older adults, this knowledge will have a direct impact on the development of new ways to prevent or remediate impairments in cognitive abilities that naturally emerge across the lifespan. The work will tell us when interventions for memory failure will have the maximum effectiveness, and will impact directly on wellbeing and independent living on older adulthood. The work relates directly to the BBSRC priority area 'Ageing research: lifelong health and wellbeing'.
我们实验室最近的工作发现了一个悖论--携带一种与老年记忆障碍相关的基因变体的年轻人似乎比没有携带这种变体的年轻人有更好的记忆力。这是令人惊讶的,因为这种变异与健康的人在大约50年的生命中的记忆缺陷有可靠的联系。此外,我们还证明,作为年轻人,携带者比非携带者对改善记忆性能的化合物--所谓的“认知增强剂”--的反应更好。这项拨款中提出的研究将帮助我们了解该基因变体携带者和非携带者的大脑有何不同,以及当人们从年轻到中年时,它们是如何变化的。我们将对携带该基因变体的中青年成年人的大脑进行成像,并将其与年龄匹配的非携带者的大脑进行比较。特别是,我们将比较在重要的日常记忆任务中使用的大脑区域的活动。这些实验将揭示,拥有变异基因是否会改善大脑中这些区域在典型和具有挑战性的情况下的使用方式。我们将确定为什么变异体的携带者从认知增强剂中获得额外的认知促进。我们认为,基因变体和认知增强剂正在刺激不同的大脑区域,两者结合在一起的附加值为基因变体的携带者带来了额外的好处。最后,我们将确定年轻携带者对认知增强药物的更好反应是否在中年继续保持不变。由于该基因的变异与健康老年人的记忆障碍有关,这一知识将对开发新的方法来预防或补救自然出现的认知能力障碍产生直接影响。这项工作将告诉我们,何时对记忆衰竭进行干预将产生最大的效果,并将直接影响老年人的幸福感和独立生活。这项工作与BBSRC的优先领域“老龄化研究:终身健康和福祉”直接相关。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures.
年轻人中的 APOE e4 多态性与注意力的改善相关,并通过独特的神经特征进行索引。
- DOI:10.1016/j.neuroimage.2012.10.010
- 发表时间:2013
- 期刊:
- 影响因子:5.7
- 作者:Rusted JM
- 通讯作者:Rusted JM
Prospective memory in young and mid age adults: does time on task degrade cue-related neural activity?
年轻人和中年人的前瞻性记忆:执行任务的时间会降低与提示相关的神经活动吗?
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:Simon L Evans
- 通讯作者:Simon L Evans
Cognitive and neural signatures of the APOE E4 allele in mid-aged adults.
- DOI:10.1016/j.neurobiolaging.2014.01.145
- 发表时间:2014-07
- 期刊:
- 影响因子:4.2
- 作者:Evans S;Dowell NG;Tabet N;Tofts PS;King SL;Rusted JM
- 通讯作者:Rusted JM
APOE E4 Carriers show prospective memory enhancement under nicotine, and evidence for specialisation within medial BA10.
- DOI:10.1038/npp.2012.230
- 发表时间:2013-03
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Acute effects of nicotine administration during prospective memory, an event related fMRI study.
尼古丁给药对前瞻性记忆的急性影响,一项事件相关的功能磁共振成像研究。
- DOI:10.1016/j.neuropsychologia.2011.04.009
- 发表时间:2011
- 期刊:
- 影响因子:2.6
- 作者:Rusted J
- 通讯作者:Rusted J
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Jennifer Rusted其他文献
Nicotine effects on retrieval-induced forgetting are not attributable to changes in arousal
尼古丁对提取引起的遗忘的影响并不是由唤醒的变化造成的
- DOI:
10.1007/s00213-007-0935-4 - 发表时间:
2007 - 期刊:
- 影响因子:3.4
- 作者:
Jennifer Rusted;T. Alvares - 通讯作者:
T. Alvares
Moving out of the laboratory: does nicotine improve everyday attention?
走出实验室:尼古丁能提高日常注意力吗?
- DOI:
- 发表时间:
2000 - 期刊:
- 影响因子:1.6
- 作者:
Jennifer Rusted;D. Caulfield;L. King;Alastair Goode - 通讯作者:
Alastair Goode
Does nicotine improve cognitive function?
尼古丁可以改善认知功能吗?
- DOI:
10.1007/bf02245580 - 发表时间:
1994 - 期刊:
- 影响因子:3.4
- 作者:
Jennifer Rusted;L. Graupner;N. O'Connell;C. Nicholls - 通讯作者:
C. Nicholls
Facilitation of children’s prose recall by the presence of pictures
- DOI:
10.3758/bf03196939 - 发表时间:
1979-09-01 - 期刊:
- 影响因子:2.100
- 作者:
Jennifer Rusted;Max Coltheart - 通讯作者:
Max Coltheart
Deprivation state but not nicotine content of the cigarette affects responding by smokers on a progressive ratio task
剥夺状态而不是香烟的尼古丁含量影响吸烟者对渐进比例任务的反应
- DOI:
- 发表时间:
1998 - 期刊:
- 影响因子:3.4
- 作者:
Jennifer Rusted;Anthony Mackee;R. Williams;Paul Willner - 通讯作者:
Paul Willner
Jennifer Rusted的其他文献
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{{ truncateString('Jennifer Rusted', 18)}}的其他基金
Rising to the Challenge: Understanding causes and consequences of neural overactivation in young adult APOE-e4 carriers
迎接挑战:了解年轻成人 APOE-e4 携带者神经过度激活的原因和后果
- 批准号:
BB/L009242/1 - 财政年份:2014
- 资助金额:
$ 50.11万 - 项目类别:
Research Grant
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