IMMUNOBIOLOGY OF AFRICAN TRYPANOSOMIASIS

非洲锥虫病的免疫生物学

• 批准号: 3133499
• 负责人: John M. Mansfield
• 金额: $ 26.09万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1992-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3133499
• 关键词: B lymphocyte; T lymphocyte; Trypanosoma; Trypanosoma brucei rhodesiense; animal morbidity; antigen presentation; antigens; antiidiotype antibody; cellular immunity; gene expression; genetic library; histopathology; host organism interaction; immunization; immunochemistry; immunogenetics; immunoglobulin idiotypes; immunoregulation; immunosuppression; laboratory mouse; laboratory rabbit; laboratory rat; macrophage; microorganism genetics; microorganism immunology; microscopy; molecular pathology; nucleic acid hybridization; protozoal antigen; radioimmunoassay; surface antigens; tissue /cell culture; trypanosomiasis; virulence

This project represents an experimental model system for the study of human and animal disease caused by the African trypanosomes. A continuation of studies which examine the immunobiological relationship between host and parasite in Trypanosoma brucei rhodesiense infected inbred mice is proposed. The specific aims of the project are (1) to define at the molecule and cellular levels the nature of host immune responses to defined epitopes of trypanosome variant-specific and invariant antigens; (2) to examine at the molecular and cellar levels the means by which infected hosts regulate parasite-specific immune responses; (3) to determine how non-MHC-associated genetic differences influence the overall resistance status of the infected host strain; and (4) to define the molecular and genetic bases of virulence expression in trypanosomes which alter host immunity and resistance characteristics. Contemporary immunology and molecular biology form the conceptual and technique framework of this project.

本项目为研究提供了一个实验模型系统 非洲锥虫引起的人类和动物疾病。 继续研究，检查免疫生物学 布氏锥虫宿主与寄生虫关系 提出了罗得西亚病毒感染的近交系小鼠。 具体目标 该项目的目的是（1）在分子和细胞上定义 水平的宿主免疫应答的性质，以确定表位的 锥虫变异体特异性和不变抗原;（2）检查 在分子和细胞水平上， 宿主调节寄生虫特异性免疫反应;（3）确定 非MHC相关的遗传差异如何影响整体 受感染宿主菌株的抗性状态;以及（4）定义 毒力表达的分子和遗传基础 改变宿主免疫力和抵抗力的锥虫 特色 现代免疫学与分子生物学 形成本项目的概念和技术框架。