Molecular control of boundary cap stem cell function

边界帽干细胞功能的分子控制

• 批准号: BB/I008373/1
• 负责人: Christiana Ruhrberg
• 金额: $ 50.75万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FI008373%2F1
• 关键词: Molecular; control; boundary; cap; stem

We wish to answer fundamental biological questions that will benefit future research into nervous system regeneration by studying a type of neural stem cells known as boundary cap stem cells. These embryonic cells reside in clusters on the borders of the spinal cord and brainstem, where nerves exit and enter to connect to the rest of the body. These clusters, the boundary caps, are thought to be important for the correct development of the nervous system in mammals. In addition, they have the potential to act as stem cells that could be used for nervous system repair and regeneration. For these reasons, we want to understand how boundary caps are formed, how they function in the embryo to aid nervous system development, and how they eventually become nerve cells and support cells to in the adult nervous system. To achieve these goals, we will explore the function of three types of molecules that were previously shown to regulate the behaviour of neurons and blood stem cells and are targetable by clinical drug therapies.

我们希望通过研究一种被称为边界帽干细胞的神经干细胞来回答一些基本的生物学问题，这些问题将有利于未来对神经系统再生的研究。这些胚胎细胞聚集在脊髓和脑干的边缘，神经在这里进出，连接到身体的其他部位。这些集群，即边界帽，被认为对哺乳动物神经系统的正确发育很重要。此外，它们还具有作为干细胞的潜力，可用于神经系统修复和再生。基于这些原因，我们想了解边界帽是如何形成的，它们在胚胎中是如何帮助神经系统发育的，以及它们最终如何成为神经细胞并支持成人神经系统的细胞。为了实现这些目标，我们将探索三种类型的分子的功能，这些分子先前被证明可以调节神经元和血液干细胞的行为，并且是临床药物治疗的靶标。

项目成果

Vascularisation is not necessary for gut colonisation by enteric neural crest cells.

• DOI: 10.1016/j.ydbio.2013.11.007
• 发表时间: 2014-01-15
• 期刊: DEVELOPMENTAL BIOLOGY
• 影响因子: 2.7
• 作者: Delalande, Jean-Marie;Natarajan, Dipa;Vernay, Bertrand;Finlay, Malcolm;Ruhrberg, Christiana;Thapar, Nikhil;Burns, Alan J.
• 通讯作者: Burns, Alan J.

Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves.

• DOI: 10.1016/j.cell.2015.07.021
• 发表时间: 2015-08-27
• 期刊: Cell
• 影响因子: 64.5
• 作者: Cattin AL;Burden JJ;Van Emmenis L;Mackenzie FE;Hoving JJ;Garcia Calavia N;Guo Y;McLaughlin M;Rosenberg LH;Quereda V;Jamecna D;Napoli I;Parrinello S;Enver T;Ruhrberg C;Lloyd AC
• 通讯作者: Lloyd AC

Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity.

• DOI: 10.4161/cam.22408
• 发表时间: 2012-11
• 期刊: Cell adhesion & migration
• 影响因子: 3.2
• 作者: Tillo M;Ruhrberg C;Mackenzie F
• 通讯作者: Mackenzie F

NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system.

• DOI: 10.1016/j.ydbio.2012.06.026
• 发表时间: 2012-09-15
• 期刊: DEVELOPMENTAL BIOLOGY
• 影响因子: 2.7
• 作者: Maden, Charlotte H.;Gomes, John;Schwarz, Quenten;Davidson, Kathryn;Tinker, Andrew;Ruhrberg, Christiana
• 通讯作者: Ruhrberg, Christiana

Neuropilins guide preganglionic sympathetic axons and chromaffin cell precursors to establish the adrenal medulla.

• DOI: 10.1242/dev.162552
• 发表时间: 2018-11-02
• 期刊: Development (Cambridge, England)
• 作者: Lumb R;Tata M;Xu X;Joyce A;Marchant C;Harvey N;Ruhrberg C;Schwarz Q
• 通讯作者: Schwarz Q