Exploiting the growth promotion and induced resistance properties of Trichoderma hamatum for improved crop productivity.

利用钩状木霉的生长促进和诱导抗性特性来提高作物生产力。

基本信息

  • 批准号:
    BB/I014691/1
  • 负责人:
  • 金额:
    $ 59.71万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2011
  • 资助国家:
    英国
  • 起止时间:
    2011 至 无数据
  • 项目状态:
    已结题

项目摘要

With the human population projected to reach 9 billion by the year 2050, unsustainable demands will be placed on global agriculture to meet future food requirements. Improvements in crops yields that have traditionally relied on plant breeding and energy intensive agriculture are unlikely to meet these needs and therefore marginal land, previously considered unsuitable for agriculture, will need to be brought into cultivation. Much of this land will have sub-optimal fertility and nutrient-poor soils requiring substantial inputs of synthetic fertilizers to support sustainable crop production. However, significant increases in the price of fertilizers mean many farmers, particularly in developing countries, cannot afford such management practises. The spiraling financial burden of fertilizers, combined with growing public anxiety of the environmental and health impacts of synthetic chemical additives, means that alternative strategies for sustainable crop production need to be examined urgently. Trichoderma strains produce a diverse array of secondary metabolites and secreted proteins. Trichoderma isolates have been shown to activate broad spectrum immunity, ameliorate a wide range of abiotic stresses such as salinity and drought, improve photosynthetic efficiency, enhance nutrient uptake, and significantly increase nitrogen use efficiency in crops. These important attributes can all contribute to the enhanced plant growth characteristics often evident upon inoculation. The positive agronomic traits of growth promotion, enhanced tolerance to abiotic stress and broad spectrum enhanced systemic immunity afforded by many Trichoderma strains are striking and unique. The ability to exploit the signaling networks activated by Trichoderma to establish these agriculturally beneficial traits requires an understanding of both the bioactive inducing molecules and the signaling networks targeted by these activators. The rapid developments in genomic and analytical technologies means this is an opportune time to exploit the amazing chemical diversity of soil micro-organisms such as Trichoderma, with the objective of improving PGP and ISR on a range of agronomically important plant species. Research conducted at Exeter has identified a novel strain of the naturally occurring rhizosphere fungus Trichoderma hamatum (strain GD12) that improves crop productivity and imparts broad spectrum enhanced immunity to pathogens in the absence of costly fertilizers and environmentally damaging agrochemicals. At present, the mechanism underlying the plant-growth-promotion and enhanced systemic resistance phenomena are unknown and this proposal lays the foundations to address the molecular basis of the inducing bioactives and the plant response pathways targeted by these bioactives. This combined knowledge is important, and necessary to contemplate translating Trichoderma PGP and ISR into the agricultural arena. This multidisciplinary research programme will use a combination of genetics, genomics and metabolomics to unravel Trichoderma PGP/ISR bioactives, capture the plant transcriptional reprogramming induced by the bioactives and identify key components of the PGP, ISR signaling networks. We will use comparative transcriptomics to characterize signaling pathways in Arabidopsis and rice activated by Trichoderma inoculation. In combination with mutant Trichoderma and Arabidopsis lines compromised in phytohormone signaling we will identify candidate signaling components/pathways that contribute to PGP and ISR. We will undertake comparative metabolic profiling using liquid chromatography mass spectrometry to characterize the bioactives and test their efficacy on different plants with the objective of developing novel natural agrochemicals.
预计到2050年,人口将达到90亿,为满足未来的粮食需求,将对全球农业提出不可持续的要求。传统上依靠植物育种和能源密集型农业来提高作物产量,不可能满足这些需要,因此,需要开垦以前被认为不适合农业的边际土地。这些土地中的大部分将具有次优的肥力和营养贫乏的土壤,需要大量的合成肥料投入,以支持可持续的作物生产。然而,化肥价格的大幅上涨意味着许多农民,特别是发展中国家的农民,负担不起这种管理费用。化肥的财政负担不断增加,加上公众对合成化学添加剂对环境和健康的影响日益担忧,这意味着迫切需要审查可持续作物生产的替代战略。木霉菌株产生多种次级代谢产物和分泌蛋白。木霉分离物已被证明激活广谱免疫,改善广泛的非生物胁迫,如盐和干旱,提高光合效率,增强营养吸收,并显着提高作物的氮利用效率。这些重要的属性都可以有助于增强植物生长特性,通常在接种后明显。许多木霉菌株具有显著的促进生长、增强对非生物胁迫的耐受性和广谱增强系统免疫力的积极农艺性状。利用木霉激活的信号网络来建立这些农业上有益的性状的能力需要理解生物活性诱导分子和这些激活剂靶向的信号网络。基因组和分析技术的快速发展意味着现在是利用土壤微生物(如木霉)惊人的化学多样性的大好时机,目的是改善一系列重要农艺植物物种的PGP和ISR。在埃克塞特进行的研究已经确定了一种新的天然根际真菌Trichoderma hamatum(菌株GD 12)菌株,该菌株可以提高作物产量,并在不使用昂贵的肥料和破坏环境的农用化学品的情况下赋予对病原体的广谱增强免疫力。目前,促进植物生长和增强系统抗性现象的机制尚不清楚,该提议为解决诱导生物活性物质的分子基础和这些生物活性物质靶向的植物响应途径奠定了基础。这种结合的知识对于考虑将木霉PGP和ISR转化到农业竞技场中是重要的和必要的。这个多学科的研究计划将使用遗传学,基因组学和代谢组学的组合来解开木霉PGP/ISR生物活性物质,捕获生物活性物质诱导的植物转录重编程,并确定PGP,ISR信号网络的关键组成部分。我们将使用比较转录组学来表征木霉接种激活的拟南芥和水稻中的信号通路。结合突变的木霉和拟南芥株系在植物激素信号传导中受损,我们将鉴定有助于PGP和ISR的候选信号传导组分/途径。我们将使用液相色谱质谱法进行比较代谢分析,以表征生物活性物质,并测试其对不同植物的功效,以开发新型天然农用化学品。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Investigating the beneficial traits of Trichoderma hamatum GD12 for sustainable agriculture-insights from genomics.
  • DOI:
    10.3389/fpls.2013.00258
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    5.6
  • 作者:
    Studholme DJ;Harris B;Le Cocq K;Winsbury R;Perera V;Ryder L;Ward JL;Beale MH;Thornton CR;Grant M
  • 通讯作者:
    Grant M
An ultra-fast metabolite prediction algorithm.
  • DOI:
    10.1371/journal.pone.0039158
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Yang ZR;Grant M
  • 通讯作者:
    Grant M
Transcriptional reprogramming underpins enhanced plant growth promotion by the biocontrol fungus Trichoderma hamatum GD12 during antagonistic interactions with Sclerotinia sclerotiorum in soil.
  • DOI:
    10.1111/mpp.12429
  • 发表时间:
    2016-12
  • 期刊:
  • 影响因子:
    4.9
  • 作者:
    Shaw S;Le Cocq K;Paszkiewicz K;Moore K;Winsbury R;de Torres Zabala M;Studholme DJ;Salmon D;Thornton CR;Grant MR
  • 通讯作者:
    Grant MR
An update: improvements in imaging perfluorocarbon-mounted plant leaves with implications for studies of plant pathology, physiology, development and cell biology.
  • DOI:
    10.3389/fpls.2014.00140
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    5.6
  • 作者:
    Littlejohn GR;Mansfield JC;Christmas JT;Witterick E;Fricker MD;Grant MR;Smirnoff N;Everson RM;Moger J;Love J
  • 通讯作者:
    Love J
Aligning extracted LC-MS peak lists via density maximization
  • DOI:
    10.1007/s11306-011-0389-x
  • 发表时间:
    2012-06-01
  • 期刊:
  • 影响因子:
    3.6
  • 作者:
    Perera, Venura;Zabala, Marta De Torres;Yang, Zheng Rong
  • 通讯作者:
    Yang, Zheng Rong
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Murray Grant其他文献

Communal weeding
  • DOI:
    10.1186/gb-2000-1-6-reports4024
  • 发表时间:
    2000-01-01
  • 期刊:
  • 影响因子:
    9.400
  • 作者:
    Murray Grant;Steve Smith
  • 通讯作者:
    Steve Smith
How clumpy is my image?
我的图像有多块状?
  • DOI:
    10.1007/s00500-014-1303-z
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    4.1
  • 作者:
    Hugo Hutt;R. Everson;Murray Grant;John Love;George R. Littlejohn
  • 通讯作者:
    George R. Littlejohn
NAD(H) and NADP(H) in plants and mammals
植物和哺乳动物中的 NAD(H) 和 NADP(H)
  • DOI:
    10.1016/j.molp.2025.05.004
  • 发表时间:
    2025-06-02
  • 期刊:
  • 影响因子:
    24.100
  • 作者:
    Danying Lu;Murray Grant;Boon Leong Lim
  • 通讯作者:
    Boon Leong Lim
Development of a lateral flow device for in‐field detection and evaluation of PCR‐based diagnostic methods for Xanthomonas campestris pv. musacearum, the causal agent of banana xanthomonas wilt
开发用于现场检测和评估香蕉黄单胞菌枯萎病病原菌黄单胞菌诊断方法的侧流装置
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    J. Hodgetts;G. Karamura;G. Karamura;G. Johnson;J. Hall;K. Perkins;F. Beed;V. Nakato;Murray Grant;D. Studholme;Neil Boonham;Julian Smith
  • 通讯作者:
    Julian Smith
Finding the functional gems in plant genomes
  • DOI:
    10.1186/gb-2003-4-12-350
  • 发表时间:
    2003-01-01
  • 期刊:
  • 影响因子:
    9.400
  • 作者:
    Alexandra M Jones;Murray Grant
  • 通讯作者:
    Murray Grant

Murray Grant的其他文献

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{{ truncateString('Murray Grant', 18)}}的其他基金

Anatomy and functions of LTP interactomes and their relationship to small RNA signals in systemic acquired resistance
LTP相互作用组的解剖和功能及其与系统获得性耐药中小RNA信号的关系
  • 批准号:
    BB/X013049/1
  • 财政年份:
    2023
  • 资助金额:
    $ 59.71万
  • 项目类别:
    Research Grant
Hong Kong Partnering Award: Next generation genetically encoded sensors to reveal primary energy metabolism in plant immune responses.
香港合作奖:下一代基因编码传感器揭示植物免疫反应中的初级能量代谢。
  • 批准号:
    BB/W018748/1
  • 财政年份:
    2022
  • 资助金额:
    $ 59.71万
  • 项目类别:
    Research Grant
Nucleoside decoys - metabolic interference in plant defence
核苷诱饵 - 植物防御中的代谢干扰
  • 批准号:
    BB/V01627X/1
  • 财政年份:
    2021
  • 资助金额:
    $ 59.71万
  • 项目类别:
    Research Grant
Xanthomonas plant diseases: mitigating existing, emerging and future threats to UK agriculture
黄单胞菌植物病害:减轻英国农业现有、新出现和未来的威胁
  • 批准号:
    BB/T010924/1
  • 财政年份:
    2020
  • 资助金额:
    $ 59.71万
  • 项目类别:
    Research Grant
China Partnering Award: Does chloroplast reactive oxygen underpin plant disease resistance?
中国合作奖:叶绿体活性氧是否支持植物抗病?
  • 批准号:
    BB/S020764/1
  • 财政年份:
    2019
  • 资助金额:
    $ 59.71万
  • 项目类别:
    Research Grant
Retaining the Ashes: The potential for ash populations to be restored following the dieback epidemic
保留灰烬:枯死流行后灰烬数量恢复的潜力
  • 批准号:
    BB/R018944/1
  • 财政年份:
    2018
  • 资助金额:
    $ 59.71万
  • 项目类别:
    Research Grant
The role of the chloroplast in activation of systemic immunity
叶绿体在激活全身免疫中的作用
  • 批准号:
    BB/R021457/1
  • 财政年份:
    2018
  • 资助金额:
    $ 59.71万
  • 项目类别:
    Research Grant
Understanding the mechanism of chloroplast immunity.
了解叶绿体免疫机制。
  • 批准号:
    BB/P002560/1
  • 财政年份:
    2017
  • 资助金额:
    $ 59.71万
  • 项目类别:
    Research Grant
Towards protecting the UK landscape; a novel method to screen for resistance to ash dieback while mitigating herbivory tradeoffs.
保护英国景观;
  • 批准号:
    BB/N021452/1
  • 财政年份:
    2016
  • 资助金额:
    $ 59.71万
  • 项目类别:
    Research Grant
Modelling hormonal crosstalk - commonalities between bacterial and fungal resistance and susceptibility networks.
模拟激素串扰 - 细菌和真菌耐药性和易感性网络之间的共性。
  • 批准号:
    BB/K005340/1
  • 财政年份:
    2012
  • 资助金额:
    $ 59.71万
  • 项目类别:
    Research Grant

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