EPIDEMIOLOGY OF ANTIBIOTIC RESISTANCE PLASMIDS

研究的长期目标是提高 了解抗菌药物的演变和多样性 全球分散的细菌群体中的耐药质粒， 为了更好地了解和控制 抗菌抗性基因 具体目标是确定EcoRI并将其计算机存档 耐药质粒的片段大小值， 抗性表型或随机从广泛的系列 隔离集合，以在此数据中检测 以前公认的稳定质粒，并进一步描绘其 分布，以检测和描绘额外的 稳定的质粒并估计其多样性，以开发方法 为了检测和分析质粒之间的较小相关性， 调查耐药质粒的流行率、多样性和同一性， 粪大肠杆菌未经治疗和未住院的人， 世界不同地区的数据， 一个质粒上可能分离株的片段大小可用统计学 重建质粒系统发育树的程序， 检测和建立涉及的区域的精细细节 重组事件，这是重要的传播， 抗菌药物耐药基因在全球分散的人群， 细菌

The long term objectives of the research are to improve understanding of the evolution and diversity of antibacterial resistance plasmids in globally dispersed populations of bacteria in order to improve understanding and control of the spread of antibacterial resistance genes. The specific aims are to determine and computer file EcoRI fragment size values for resistance plasmids selected by resistance phenotype or randomly from an extensive series of isolate collections, to detect in this data further copies of previously recognized stable plasmids and further delineate their distributions, to detect and delineate distribution of additional stable plasmids and estimate their diversity, to develop methods for detecting and analyzing lesser relatedness between plasmids, to survey resistance plasmid prevalence, diversity and identity in fecal E. coli from untreated and unhospitalized humans in different parts of the world, to adapt and apply to data on fragment sizes of may isolates on one plasmid available statistical programs to reconstruct the plasmid's phylogenetic tree, and to detect and establish fine detail of regions involved in recombinational events that are significant for the spread of antibacterial resistance genes in globally dispersed populations of bacteria.