GROWTH FACTORS IN BENIGN PROSTATIC HYPERPLASIA

临床证据表明，类固醇并不是唯一的影响因素 在良性前列腺增生症(BPH)的发生发展中起重要作用。我们发现了 高分子有丝分裂因子呈现非人前列腺 匀浆和表达的前列腺液。因此，我们将 提纯这些非甾体前列腺丝分裂因子(PrGF)并比较 它们与其他已知的有丝分裂原有关。我们建议制作抗病毒的单抗。 这些因子及其在前列腺和前列腺癌中的含量 临床正常的前列腺癌患者和前列腺癌患者的分泌物 良性前列腺增生症、慢性细菌性前列腺炎或前列腺 恶毒。我们将确定这些前列腺生长因子是否可以 与蓖麻毒素有关，以及这些PrGF嵌合毒素是否可以 对良性前列腺增生症的间质增生有良好的治疗作用。这些研究 可能有助于阐明非类固醇生长因子在 良性前列腺增生症的发展以及前列腺的其他病理状态。 此外，它可能导致一种非手术方法来治疗常见的 前列腺增生症的男性问题。目前，手术是唯一有效的治疗方法。 治疗良性前列腺增生症。然而，许多患有前列腺增生症的男性 年事已高，手术风险较低。因此，最好是有一个 为这些患者提供了一种有效的非手术替代方案。

Clinical evidence suggests that steroids are not the only factors involved in the development of benign prostatic hyperplasia (BPH). We have found high molecular weight mitogenic factors present inhuman prostatic homogenates and expressed prostatic secretions. We are therefore going to purify these non-steroidal prostate mitogenic factors (PrGF) and compare them to other known mitogens. We propose to make monoclonal antibodies to these factors and quantitate their amounts in prostate and prostatic secretions of men with a clinically normal prostate gland and patients with benign prostatic hyperplasia, chronic bacterial prostatitis or prostatic malignancy. We will ascertain whether these prostate growth factors can be linked to toxins such as ricin and whether these PrGF chimeric toxins could be effective in debulking the stromal hyperplasia of BPH. These studies may help elucidate the role of non-steroidal growth factors in the development of BPH as well as other pathological states of the prostate. Further it may lead to a nonsurgical method for treatment of the common male problem of BPH. Presently, surgery is the only effective method of treatment for benign prostatic hyperplasia. However, many men with BPH are elderly and are poor surgical risks. Thus, it would be desirable to have an effective nonsurgical alternative for these individuals.