ULTRASONIC PROPERTIES OF NORMAL AND PATHOLOGICAL TISSUES

正常和病理组织的超声特性

• 批准号: 2088667
• 负责人: PETER D EDMONDS
• 金额: $ 17.46万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-01 至 1995-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2088667
• 关键词: biopsy; breast neoplasms; carcinoma; computed axial tomography; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder classification; human tissue; image processing; mammography; noninvasive diagnosis; pathology; sound impedance; ultrasonography

The objective of the proposed research is to relate ultrasound attenuation and backscatter coefficients, and their frequency dependencies,and their sound speed to the pathological state of breast tissue. These data are required for adequate assessment of the potential of ultrasound transmission imaging and ultrasound computed tomography when combined with ultrasound reflection imaging in breast cancer detection. Methodology: Freshly excised biopsy specimens will be interrogated by finely focused ultrasound beams. Translation of the sample holder under computer control permits interrogation at selected locations in the specimen. Data will be obtained over the frequency range 3 to 9 MHz and stored for subsequent analysis. Time-of-flight data will yield ultrasound speed at each location; insertion loss data will yield attenuation coefficients. Transmitted ultrasound power will be detected by a phase-insensitive acousto-electric receiver, thereby avoiding phase-cancellation artifacts; backscattered ultrasound will be detected by a focused piezoelectric transmitter-receiver. Improvements to the apparatus will be undertaken to increase speed of data acquisition, maximize spatial resolution, and increase sensitivity of signal detection. Detailed histological examination and coding will permit analysis to correlate ultrasonic data with pathological state. In particular, we seek to discriminate benign from malignant states. Discriminant analysis using the jackknifing technique, classification and regression trees, and neural net analyses will be applied.

拟议研究的目的是将超声衰减 和后向散射系数，以及它们的频率依赖性，以及它们的 声速对乳腺组织病理状态的影响。这些数据 需要充分评估超声的潜力 透射成像和超声计算机断层扫描， 超声反射成像在乳腺癌检测中的应用方法学： 新鲜切除的活检标本将通过精细聚焦显微镜进行检查。 超声波束在计算机控制下平移样品保持器 允许在样本中的选定位置进行询问。数据将 在3至9 MHz的频率范围内获得，并存储用于随后的 分析.飞行时间数据将产生每个位置处的超声速度; 插入损耗数据将产生衰减系数。发送 超声功率将由相位不敏感的声电 接收器，从而避免相位抵消伪影;反向散射 超声将被聚焦的压电传感器检测到 收发两用机将对该装置进行改进， 提高数据采集速度，最大化空间分辨率， 提高了信号检测灵敏度。详细组织学检查 并且编码将允许分析以将超声数据与 病态特别是，我们试图区分良性和 恶性国家使用折刀技术的判别分析， 分类和回归树，神经网络分析将是 应用。

项目成果

Ultrasound tissue characterization of breast biopsy specimens.

乳腺活检标本的超声组织表征。

• DOI: 10.1177/016173469101300204
• 发表时间: 1991
• 期刊: Ultrasonic imaging
• 影响因子: 2.3
• 作者: Edmonds,PD;Mortensen,CL;Hill,JR;Holland,SK;Jensen,JF;Schattner,P;Valdes,AD
• 通讯作者: Valdes,AD

Ultrasound tissue characterization of breast biopsy specimens: expanded study.

乳腺活检标本的超声组织表征：扩展研究。

• DOI: 10.1177/016173469601800304
• 发表时间: 1996
• 期刊: Ultrasonic imaging
• 影响因子: 2.3
• 作者: Mortensen,CL;Edmonds,PD;Gorfu,Y;Hill,JR;Jensen,JF;Schattner,P;Shifrin,LA;Valdes,AD;Jeffrey,SS;Esserman,LJ
• 通讯作者: Esserman,LJ