ULTRASONIC PROPERTIES OF NORMAL AND PATHOLOGICAL TISSUES

正常和病理组织的超声特性

• 批准号: 3172096
• 负责人: PETER D EDMONDS
• 金额: $ 17.37万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-03-01 至 1990-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3172096
• 关键词: carcinoma; computed axial tomography; diagnosis design /evaluation; diagnosis quality /standard; human tissue; image processing; mammography; sound impedance; ultrasonography

The purpose of the proposed research is to determine in detail the dependence ultrasonic attenuation and sound speed on the pathological state of breast tissue. These data are required for an adequate assessment of the potential of ultrasound transmission imaging and computed tomography in breast cancer detection. Freshly excised biopsy specimens will be interrogated by finely focused ultrasound beam, and the transmitted ultrasound will be detected by a phase-insensitive acoustoelectric receiver, thereby eliminating artifacts due to phase cancellation that might invalidate most attenuation measurements previously reported in the literature. The sample holder will be translated in a raster pattern to obtain data at up to 256 locations in the specimen. Data will be obtained over the frequency range 2 to 9 MHz and stored for subsequent analysis. Time-of-flight data will yield ultrasound speed at each location. Detailed histological examination and reporting will enable ultrasonic data to be correlated with the pathological state-this will be performed with unprecedented accuracy of registration. Results of this research will permit an assessment of the potential of ultrasound transmission imaging based on attenuation differences in the breast. They will also be pertinent to the interpretation of B-scan images and computed tomographic images.

拟议研究的目的是详细确定 超声衰减和声速对病理状态的依赖性 乳房组织。 这些数据是充分评估 超声透射成像和计算机断层扫描在 乳腺癌检测。 将新鲜切除的活检标本 被精细聚焦的超声波束询问， 超声将被相位不敏感的声电检测器检测到， 接收机，从而消除由于相位抵消造成的伪像， 可能会使以前报告的大多数衰减测量无效， 文学 样品保持器将以光栅模式平移， 在样本中获得多达256个位置的数据。 将获得数据 在2至9 MHz的频率范围内，并存储用于随后的分析。 飞行时间数据将产生每个位置处的超声速度。 详细的组织学检查和报告将使超声数据 与病理状态相关-这将与 前所未有的精准定位。 这项研究的结果将 允许评估超声透射成像的潜力 根据乳房中的衰减差异。 他们还将 与B扫描图像和计算机断层扫描的解释有关 图像.