ULTRASONIC PROPERTIES OF NORMAL AND PATHOLOGICAL TISSUES

正常和病理组织的超声特性

• 批准号: 3172095
• 负责人: PETER D EDMONDS
• 金额: $ 18.44万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-03-01 至 1987-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3172095
• 关键词: carcinoma; computed axial tomography; diagnosis quality /standard; human tissue; image processing; mammography; sound impedance; ultrasonography

The purpose of the proposed research is to determine in detail the dependence ultrasonic attenuation and sound speed on the pathological state of breast tissue. These data are required for an adequate assessment of the potential of ultrasound transmission imaging and computed tomography in breast cancer detection. Freshly excised biopsy specimens will be interrogated by finely focused ultrasound beam, and the transmitted ultrasound will be detected by a phase-insensitive acoustoelectric receiver, thereby eliminating artifacts due to phase cancellation that might invalidate most attenuation measurements previously reported in the literature. The sample holder will be translated in a raster pattern to obtain data at up to 256 locations in the specimen. Data will be obtained over the frequency range 2 to 9 MHz and stored for subsequent analysis. Time-of-flight data will yield ultrasound speed at each location. Detailed histological examination and reporting will enable ultrasonic data to be correlated with the pathological state-this will be performed with unprecedented accuracy of registration. Results of this research will permit an assessment of the potential of ultrasound transmission imaging based on attenuation differences in the breast. They will also be pertinent to the interpretation of B-scan images and computed tomographic images.

拟议研究的目的是详细确定 超声衰减和声速与病理状态的关系 乳房组织。这些数据是进行充分评估所必需的 超声透射式成像和计算机体层摄影术的潜力 乳腺癌检测。新切除的活组织检查样本将 由精细聚焦的超声束询问，并发射 超声波将由一种相位不敏感的声电器件检测 接收器，从而消除由于相位抵消而产生的伪影 可能会使先前在 文学。样本架将以栅格图案进行平移以 获取样本中多达256个位置的数据。将获得数据 在2至9 MHz的频率范围内，并存储以供后续分析。 飞行时间数据将得出每个位置的超声波速度。 详细的组织检查和报告将使超声数据成为可能 与病理状态相关-这将通过以下方式执行 前所未有的精确度。这项研究的结果将 允许对超声传输成像的潜力进行评估 根据乳房中的衰减差异。他们也将成为 与B超图像和计算机断层扫描的解释相关 图像。