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ACOUSTIC NONLINEARITY FOR TISSUE CHARACTERIZATION

用于组织表征的声学非线性

基本信息

批准号：
3181718
负责人：
CHANDRA M SEHGAL
金额：
$ 12.87万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
起止时间：
1986-03-01 至 1992-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3181718
关键词：
computer assisted medical decision making computer simulation image processing mathematical model membrane structure molecular biology nuclear magnetic resonance spectroscopy online computer sound frequency sound impedance tissue resource /registry tomography ultrasonography

项目摘要

This proposal is a collaborative project between the members of the Ultrasonic and Magnetic Resonance Imaging Laboratories and the Department of Pathology at the Mayo Foundation. The overall goal of this project is to obtain insight into the mechanisms that interrelate acoustic nonlinearity and sound speed parameters of tissues to their intrinsic properties, and to exploit this information to construct images that display the intrinsic properties of tissues, viz., its composition. We have previously made extensive measurements of acoustic nonlinearity parameter (B/A) and sound speed (c) in excised human tissues and numerous model liquids. On the basis of these measurements we have established that the magnitude of these acoustic parameters relate quantitatively to the volume fractions of the constituents of tissues. Also, we have shown that these parameters can be used with the aid of mathematieal modeling to elueidate the physical state of water in tissues. The implication of these results is that any specific disease process that changes tissue composition should be detectable by observing the changes in the magnitude of these acoustic parameters. That is, B/A and in are suitable candidates for the purpose of tissue characterization and imaging. The current proposal consists of three specifie aims: 1) to validate the hypothesis that the 1 phenomena that give rise to acoustic nonlinearity or, are responsible for finite sound speed, occur due to perturbations at molecular level and less likely at the cellular level; 2) to develop, implement and evaluate three different methods (frequency mixing, amplitude modulation and pulse reversal) to make images of the nonlinearity parameter; and 3) to use mixture laws and acoustic data to construct images of tissues displaying two-dimensional distributions of the composition of tissues.

这项提议是联合国超声和磁共振成像实验室和梅奥基金会病理学系。总目标这个项目的主要目的是深入了解声学非线性和声速参数之间的相互关系组织的内在属性，并利用这一点用于构造图像的信息，该图像显示内部组织的特性，即其组成。我们之前已经对声学进行了广泛的测量离体人的非线性参数(B/A)和声速(C) 组织和大量的模型液体。在此基础上我们已经确定了这些的大小声学参数与体积分数有定量关系组织的成分。此外，我们已经证明了这些参数可以在数学建模的帮助下使用来淋洗出组织中水的物理状态。言下之意在这些结果中，任何特定的疾病过程都会改变通过观察变化，应该可以检测到组织成分这些声学参数的大小。即B/A和 In是用于组织的合适的候选者表征和成像。目前的建议包括三个具体目标：1) 证实这一假设，即1现象的产生声学非线性或有限声速的原因，由于分子水平上的微扰而发生，而在细胞级别；2)开发、实施和评估三个不同的方法(混频、调幅和脉冲反转)制作非线性参数的图像；以及3) 利用混合定律和声学数据构建组织图像显示组成的二维分布纸巾。