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Architecture of a biofilm

生物膜的结构

基本信息

批准号：
BB/P001335/1
负责人：
Nicola Stanley-Wall
金额：
$ 340.42万
依托单位：
University of Dundee
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FP001335%2F1
关键词：
Architecture biofilm

项目摘要

Bacteria are small single-celled organisms that cannot be seen with the naked eye. They are found in the majority of environments and exert influence on our daily lives. One reason that explains how bacteria manage this is the fact that they team-up to form social communities called "biofilms", which are the equivalent of human cities but made from bacteria. Once living in these social communities, the resident bacteria can perform a wide range of processes, and these can in turn be exploited by us, for example in sewage breakdown or in stimulating plant growth and plant protection. However, there can be negative consequences as biofilms are the cause of many chronic infections and industrial biofouling issues. The defining feature of a biofilm is that the bacteria make a "sticky glue" called the biofilm matrix that holds the cells together and protects them from changes in the environment. This protection can result in resistance to antibiotics and other cleaning agents. Given the diverse range of processes - both positive and negative - that biofilms have been associated with, it is critical that we learn how to manipulate biofilms for our own advantage. This will require understanding how the biofilm matrix is constructed and how the different components made by the bacteria to form the matrix interact. Currently very limited information is available and given the complexity of the problem, real impact can only be achieved using a multidisciplinary approach. Our research team has been assembled to combine the skills required for success. Our ultimate goal is to build and utilise artificial biofilms. Our aim is to determine the basic rules for the structure and function of biofilms that will allow for the advantageous manipulation of both natural and artificial functional bacterial communities.

细菌是一种小的单细胞生物，肉眼无法看到。它们存在于大多数环境中，并对我们的日常生活产生影响。解释细菌如何做到这一点的一个原因是，它们合作形成称为“生物膜”的社会社区，这相当于人类城市，但由细菌组成。一旦生活在这些社会社区中，常驻细菌可以执行各种各样的过程，这些过程反过来又可以被我们利用，例如在污水分解或刺激植物生长和植物保护中。然而，由于生物膜是许多慢性感染和工业生物污染问题的原因，因此可能存在负面后果。生物膜的定义特征是细菌产生一种称为生物膜基质的“粘性胶水”，将细胞固定在一起并保护它们免受环境变化的影响。这种保护可能导致对抗生素和其他清洁剂的耐药性。考虑到生物膜所涉及的各种过程--无论是积极的还是消极的--我们必须学会如何操纵生物膜以获得我们自己的优势。这将需要了解生物膜基质是如何构建的，以及细菌形成基质的不同成分如何相互作用。目前可获得的信息非常有限，鉴于问题的复杂性，只有采用多学科办法才能取得真实的影响。我们的研究团队已被组装成联合收割机的成功所需的技能。我们的最终目标是建立和利用人工生物膜。我们的目标是确定生物膜的结构和功能的基本规则，这将允许对天然和人工功能性细菌群落进行有利的操纵。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Defining early steps in Bacillus subtilis biofilm biosynthesis.

DOI：
10.1128/mbio.00948-23
发表时间：
2023-10-31
期刊：
MBIO
影响因子：
6.4
作者：
Arbour, Christine A.;Nagar, Rupa;Bernstein, Hannah M.;Ghosh, Soumi;Al-Sammarraie, Yusra;Dorfmueller, Helge C.;Ferguson, Michael A. J.;Stanley-Wall, Nicola R.;Imperiali, Barbara
通讯作者：
Imperiali, Barbara

Lateral interactions govern self-assembly of the bacterial biofilm matrix protein BslA.

DOI：
10.1073/pnas.2312022120
发表时间：
2023-11-07
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Arnaouteli S;Bamford NC;Brandani GB;Morris RJ;Schor M;Carrington JT;Hobley L;van Aalten DMF;Stanley-Wall NR;MacPhee CE
通讯作者：
MacPhee CE

Images of Microbiology

微生物学图像