ROLE OF VISION IN ETIOLOGY OF AXIAL MYOPIA

视力在轴性近视病因学中的作用

• 批准号: 3257111
• 负责人: JOSHUA WALLMAN
• 金额: $ 21.58万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-12-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3257111
• 关键词: Prosimii; animal developmental psychology; chickens; extracellular matrix; eye accommodation; eye disorder diagnosis; eye refraction disorder; histogenesis; infant animal; laboratory rabbit; laboratory rat; myopia; neural information processing; pathologic process; retina; retinal ganglion; sclera; tetrodotoxin; visual deprivation; visual stimulus

This work has the long-term goal of understanding myopia in the context of the biological processes by which the growth of the eye is controlled. It seems reasonable to view myopia not as a disease state, but as a defect in the process by which the eye grows toward being emmetropic (that is, neither myopic nor hyperopic). The proposal seeks to determine at what levels the control over the growth of the young eye is exerted. Specifically, we find that there is a retinal level of control, manifested by visual deprivation of a part of the retina causing the growth of the sclera only in the deprived region, apparently without the participation of the brain. We propose to study this by raising birds with one region of the retina deprived of form vision and comparing the refractive status and size of the deprived region with the visually experienced region. Then we will do the same in animals with the optic nerve severed. Preliminary indications are that visual deprivation can still produce a local myopic region even under these conditions. If simple form deprivation causes severe myopia, it may be the case that the simple chaotic visual stimulation of a strobe light can prevent myopia from developing. We propose to test this in several species. We suspect that it is not the case that all control of the growth of the eye comes from within; we plan to assess the role of the brain in experimental myopia by making lesions in the Edinger-Westphal nucleus as well as by cutting the optic nerve. We also plan to study the process by which some eyes, such as those of chicks, can recover from myopia, whereas others cannot. We wish to explore the possibility that the same internal factors that determine an individual's susceptibility to myopia also determine its ability to recover from the myopia.

这项工作的长期目标是了解近视 眼睛生长的生物学过程的背景 被控制。 将近视视为疾病似乎是合理的 状态，但作为眼睛生长的过程中的缺陷 要成为膜的（即，既不是近视也不是远视）。 该提案旨在确定控制的层次 年轻的眼睛的生长被施加了。 具体来说，我们发现 有视网膜控制水平，由视觉体现 剥夺了视网膜的一部分，导致 仅在被剥夺地区的巩膜，显然没有 大脑的参与。 我们建议通过提高来研究这一点 视网膜一个区域的鸟类被剥夺了形式的视野和 比较被剥夺区域的折射状态和大小 与视觉上经验丰富的区域。 然后我们将在 具有视神经的动物被切断。 初步适应症 这种视觉剥夺仍然可以产生当地的近视区域 即使在这些条件下。 如果简单的剥夺会导致严重的近视，那可能是 简单的混乱视觉刺激的频率 可以防止近视发展。 我们建议在 几个物种。 我们怀疑并非所有控制增长的控制 眼睛来自内部；我们计划评估大脑的作用 在实验近视中，通过在Edinger-Westphal中进行病变 细胞核以及切割视神经。 我们还计划研究一些眼睛，例如 那些小鸡可以从近视中恢复过来，而其他人则不能。 我们希望探索相同内部因素的可能性 这也决定了个人对近视的敏感性 确定其从近视中恢复的能力。