DYSTONIA TREATMENT BY BOTULINUM TOXINS

描述：（主要研究者摘要）肉毒杆菌A毒素具有 成为治疗局灶性肌张力障碍的有用药物。 主要 这种方法的问题是，一些患者会产生抗体， 药物，几乎所有人都希望看到它持续更长的时间后， 注射 在这个项目中，我们将在动物和人类身上开发和测试 肉毒毒素B、D、E、F对眼睑及眼外肌的影响 肌肉功能，以确定： 1)如果对A型肉毒杆菌毒素产生耐药性的患者可以 其他类型的帮助; 2)如果这些毒素与目前使用的A型毒素有不同的效果， 毒素; 3)如果毒素在一起使用时是协同的， 效果或作用时间比单独使用时更长; 4)如果毒素的组合比单个毒素的抗原性低。

DESCRIPTION: (Principal Investigator's Abstract) Botulinum A toxin has emerged as a useful drug for treatment of focal dystonias. The major problems with this approach are so that some patients develop antibodies to the drug, and almost all would like to see it last longer after each injection. In this project we will develop and test in animals and humans the effect of botulinum toxins B, D, E and F on eyelid and extraocular muscle function, to determine: 1) if patients who have become resistant to type A botulinum toxin can be helped by other types; 2) if these toxins have different effects than the currently used type A toxin; 3) if toxins are synergistic when used together, having either greater effect or greater duration of action than when used singly; 4) if combinations of toxins are less antigenic than individual toxins.