课题基金 / 基金详情

SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE

SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE
选择性去除眼外肌
批准号：
2669595
负责人：
ALAN B SCOTT
金额：
$25.33万
依托单位：
SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-08-01 至 2001-07-31
来源：
https://reporter.nih.gov/project-details/2669595
关键词：
Primates denervation extraocular muscle eye coordination disorder eye laser surgery eye movements eye surgery laboratory rabbit microsurgery muscle function nonhuman therapy evaluation postoperative state saccades smooth pursuit eye movement technology /technique development

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中文摘要
翻译
描述：目的1定义了人类眼外的显微外科解剖结构 铒激光程序开发所需的肌肉。 目的2 代表了适应商业铒的设计/开发阶段 激光用于选择性减弱眼外肌。 旨在 图3和图4使用兔子模型来开发特定于 有针对性地去除纵向肌肉条和去神经支配， 眼外肌的特定部分。 目标5适用于目标 肌肉妥协程序开发的兔子到一个亚人灵长类动物 模型中，肌肉形态和定量眼球运动 行为是紧密相关的。 Aim 6代表人类试点研究 需要设计的临床试验的治疗开发， 提议
英文摘要
DESCRIPTION: Aim 1 defines the microsurgical anatomy of human extraocular muscle that is needed for erbium laser procedure development. Aim 2 represents a design/development phase in adapting a commercial erbium laser for the purpose of selective weakening of extraocular muscle. Aims 3 and 4 use a rabbit model to develop laser applications specific for the targeted removal of a longitudinal muscle strip and denervation of selected segments of extraocular muscle. Aim 5 applies the targeted muscle compromise procedures developed in the rabbit to a subhuman primate model in which both muscle morphology and quantitative eye movement behavior can be tightly correlated. Aim 6 represents human pilot studies needed for design of clinical trials for the therapy developed in this proposal.
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