RICIN REDUCTION OF MUSCLE FUNCTION

蓖麻毒素降低肌肉功能

• 批准号: 3265531
• 负责人: ALAN B SCOTT
• 金额: $ 13.85万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3265531
• 关键词: blood chemistry; central nervous system disorders; dosage; drug administration routes; drug adverse effect; electromyography; electron microscopy; extraocular muscle; eye movements; eyelids; heart function; histology; injection /infusion; kidney function; laboratory rabbit; liver function; microscopy; muscle function; muscle pharmacology; neuronal transport

This project seeks to determine the dose and the method of injection of ricin, which will permanently reduce eyelid and oculo-rotary muscle function in the rabbit without excessive adverse local or systemic side effects. Reduction in muscle size, muscle regeneration, and other effects on the target muscle will be assessed by functional tests and by light and electronmicroscopy. Effect on adjacent tissues will be assessed by clinical examination and by histology. Effects of neuron transport to and within the central nervous system will be assessed by histology. Systemic effects will be monitored by tests of liver, renal and cardiac function and by histology of these organs. If these experiments are successful, this approach and these data will form the basis of an experimental, clinical drug treatment for focal dystonias.

该项目旨在确定剂量和注射方法， 蓖麻毒素，这将永久减少眼睑和眼旋转肌 在家兔中发挥作用，无过度的局部或全身不良反应 方面的影响. 减少肌肉大小，肌肉再生和其他 对目标肌肉的影响将通过功能测试和 光学和电子显微镜。 对邻近组织的影响 通过临床检查和组织学评估。 神经元的作用 将通过以下方法评估向中枢神经系统和在中枢神经系统内的转运： 组织学 将通过肝、肾、 和心脏功能以及这些器官的组织学。 如果这些 实验是成功的，这种方法和这些数据将形成 局灶性肌张力障碍的实验性临床药物治疗的基础。