RICIN REDUCTION OF MUSCLE FUNCTION

本项目旨在确定安慰剂的剂量和注射方法 蓖麻毒素，会永久减少眼皮和眼球旋转肌肉 兔的功能没有过多的局部或全身不良反应 效果。减少肌肉大小、肌肉再生和其他 对目标肌肉的影响将通过功能测试和 光学显微镜和电子显微镜。对邻近组织的影响将是 通过临床检查和组织学进行评估。神经元的作用 中枢神经系统的运输和内部运输将通过以下方式进行评估 组织学。全身性影响将通过肝、肾测试进行监测 心脏功能和这些器官的组织学。如果这些 实验是成功的，这种方法和这些数据将形成 一种实验性的临床药物治疗局灶性肌张力障碍的基础。

This project seeks to determine the dose and the method of injection of ricin, which will permanently reduce eyelid and oculo-rotary muscle function in the rabbit without excessive adverse local or systemic side effects. Reduction in muscle size, muscle regeneration, and other effects on the target muscle will be assessed by functional tests and by light and electronmicroscopy. Effect on adjacent tissues will be assessed by clinical examination and by histology. Effects of neuron transport to and within the central nervous system will be assessed by histology. Systemic effects will be monitored by tests of liver, renal and cardiac function and by histology of these organs. If these experiments are successful, this approach and these data will form the basis of an experimental, clinical drug treatment for focal dystonias.